Development of a de novo cerebral arteriovenous malformation in a child with sickle cell disease and moyamoya arteriopathy: Case report

Brian A. O'Shaughnessy, Arthur J. DiPatri, Richard J. Parkinson, H. Hunt Batjer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The authors report the unique case of a 6-year-old African-American girl with sickle cell disease (SCD) and an associated moyamoya arteriopathy who developed a de novo arteriovenous malformation (AVM) of the cerebral circulation. Based on preoperative cerebral angiography, computerized tomography angiography, and magnetic resonance imaging, the incidentally discovered lesion was originally thought to be a direct arteriovenous fistula with an associated varix. At surgery, however, a 1.5-cm AVM was identified adjacent to the deep surface of the varix, and it was successfully resected. The diagnosis of cerebral AVM was then confirmed histopathologically. Based on a review of the literature, no published correlation between cerebral AVMs and SCD exists. In addition to reporting this case, the authors provide a description of AVM pathogenesis, with particular emphasis on acquired AVMs of the cerebral circulation.

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalJournal of neurosurgery
Volume102 PEDIATRICS
Issue numberSUPPL. 2
DOIs
StatePublished - Mar 1 2005

Keywords

  • Arteriovenous malformation
  • Moyamoya
  • Pediatric neurosurgery
  • Sickle cell disease
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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