Development of a high resolution MRI intracranial atherosclerosis imaging phantom

Ju Yu Chueh, Kajo Van Der Marel, Matthew J. Gounis, Todd Lematty, Truman R. Brown, Sameer A. Ansari, Timothy J. Carroll, Amanda K. Buck, Xiaohong Joe Zhou, A. Rano Chatterjee, Robert M. King, Hui Mao, Shaokuan Zheng, Olivia W. Brooks, Jeff W. Rappleye, Richard H. Swartz, Edward Feldmann, Tanya N. Turan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background and purpose Currently, there is neither a standard protocol for vessel wall MR imaging of intracranial atherosclerotic disease (ICAD) nor a gold standard phantom to compare MR sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD. Materials and methods A patient specific injection mold was 3D printed to construct a geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel was infused into the core shell mold to form the stenotic artery. The ICAD phantom incorporated materials mimicking a stenotic vessel and plaque components, including fibrous cap and lipid core. Two phantoms were scanned using high resolution cone beam CT and compared with four different 3 T MRI systems across eight different sites over a period of 18 €months. Inter-phantom variability was assessed by lumen dimensions and contrast to noise ratio (CNR). Results Quantitative evaluation of the minimum lumen radius in the stenosis showed that the radius was on average 0.80 €mm (95% CI 0.77 to 0.82 mm) in model 1 and 0.77 €mm (95% CI 0.74 to 0.81 mm) in model 2. The highest CNRs were observed for comparisons between lipid and vessel wall. To evaluate manufacturing reproducibility, the CNR variability between the two models had an average absolute difference of 4.31 (95% CI 3.82 to 5.78). Variation in CNR between the images from the same scanner separated by 7 €months was 2.5-6.2, showing reproducible phantom durability. Conclusions A plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multicenter high resolution MRI standardization.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalJournal of neurointerventional surgery
Volume10
Issue number2
DOIs
StatePublished - Feb 2018

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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