Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine

M. S. Rao; P. Pour

doi:10.1016/S0304-3835(78)80007-X

Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine

M. S. Rao^*, P. Pour

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Cancer Letters
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(78)80007-X
State	Published - Jul 1978

Keywords

BHP
BOP
DPN
N-nitrosobis(2-hydroxypropyl)amine
N-nitrosobis(2-oxopropyl)amine
N-nitrosobispropylamine
s.c.
subcutaneous

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(78)80007-X

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title = "Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine",

abstract = "N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.",

keywords = "BHP, BOP, DPN, N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine, N-nitrosobispropylamine, s.c., subcutaneous",

author = "Rao, {M. S.} and P. Pour",

year = "1978",

month = jul,

doi = "10.1016/S0304-3835(78)80007-X",

language = "English (US)",

volume = "5",

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journal = "Cancer Letters",

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TY - JOUR

T1 - Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine

AU - Rao, M. S.

AU - Pour, P.

PY - 1978/7

Y1 - 1978/7

N2 - N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.

AB - N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.

KW - BHP

KW - BOP

KW - DPN

KW - N-nitrosobis(2-hydroxypropyl)amine

KW - N-nitrosobis(2-oxopropyl)amine

KW - N-nitrosobispropylamine

KW - s.c.

KW - subcutaneous

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U2 - 10.1016/S0304-3835(78)80007-X

DO - 10.1016/S0304-3835(78)80007-X

M3 - Article

C2 - 210926

AN - SCOPUS:0018144655

SN - 0304-3835

VL - 5

SP - 31

EP - 34

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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