Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine

M. S. Rao*, P. Pour

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalCancer Letters
Volume5
Issue number1
DOIs
StatePublished - Jul 1978

Keywords

  • BHP
  • BOP
  • DPN
  • N-nitrosobis(2-hydroxypropyl)amine
  • N-nitrosobis(2-oxopropyl)amine
  • N-nitrosobispropylamine
  • s.c.
  • subcutaneous

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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