Development of the mammalian lymphatic vasculature

Ying Yang, Guillermo Oliver*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

The two vascular systems of our body are the blood and lymphatic vasculature. Our understanding of the cellular and molecular processes controlling the development of the lymphatic vasculature has progressed significantly in the last decade. In mammals, this is a stepwise process that starts in the embryonic veins, where lymphatic EC (LEC) progenitors are initially specified. The differentiation and maturation of these progenitors continues as they bud from the veins to produce scattered primitive lymph sacs, from which most of the lymphatic vasculature is derived. Here, we summarize our current understanding of the key steps leading to the formation of a functional lymphatic vasculature.

Original languageEnglish (US)
Pages (from-to)888-897
Number of pages10
JournalJournal of Clinical Investigation
Volume124
Issue number3
DOIs
StatePublished - Mar 3 2014

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Development of the mammalian lymphatic vasculature'. Together they form a unique fingerprint.

Cite this