Development of the middle latency response in an animal model and its relation to the human response

Nina Kraus*, D. Ian Smith, Therese McGee, Laszlo Stein, Cheryl Cartee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Although the clinical use of the middle latency response (MLR) in adults is fairly straightforward, its use is complicated by maturational changes that continue throughout the first decade of life. In order to telescope the time period of this long developmental course, we have approached the study of MLR maturation using the gerbil as an animal model. The course of MLR obtained over the temporal lobe development was characterized in the Monogolian gerbil ranging in age from 10 days to 3 months of life. The adult gerbil MLR consists of two positive peaks (A and C) at 11 and 25 ms, respectively, and a negative component (B) at 16 ms. These components emerge in a systematic fashion as a function of age. The present work supports a strong age effect of increased MLR detectability in the gerbil, similar to findings reported for humans. Wave A was infrequently detected in young animals, but when present, it occurred at adult latencies. The latency of waves B and C decreased systematically with age. The amplitude of all components increased with age, similar to findings in humans. The fact that adult-like thresholds were obtained shortly after birth indicates that when present, MLRs may be a good index of hearing threshold. Effects of stimulating across a wide range of intensities were described. The gerbil model appears appropriate for the study of development of the central auditory system function.

Original languageEnglish (US)
Pages (from-to)165-176
Number of pages12
JournalHearing research
Issue number2
StatePublished - 1987


  • Development
  • Maturation auditory evoked potential
  • Middle latency response

ASJC Scopus subject areas

  • Sensory Systems


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