Development of the renal glomerulus: Good neighbors and good fences

Susan E. Quaggin, Jordan A. Kreidberg*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations

Abstract

The glomerulus of the mammalian kidney is an intricate structure that contains an unusual filtration barrier that retains higher molecular weight proteins and blood cells in the circulation. Recent studies have changed our conception of the glomerulus from a relatively static structure to a dynamic one, whose integrity depends on signaling between the three major cell lineages: podocytes, endothelial and mesangial cells. Research into the signaling pathways that control glomerular development and then maintain glomerulair integrity and function has recently identified several genes, such as the nephrin and Wilms' tumor 1 genes, that are mutated in human kidney disease.

Original languageEnglish (US)
Pages (from-to)609-620
Number of pages12
JournalDevelopment
Volume135
Issue number4
DOIs
StatePublished - Feb 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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