Development of Treatments for Localized Prostate Cancer in Patients Eligible for Active Surveillance: U.S. Food and Drug Administration Oncology Center of Excellence Public Workshop

Chana Weinstock, Daniel Suzman, Paul Kluetz, John Baxley, Charles Viviano, Amna Ibrahim, Jonathan Jarow, Raejshwari Sridhara, Ke Liu, Peter Carroll, Scott Eggener, Jim C. Hu, Maha Hussain, Martin King, Eric Klein, Terry Kungel, Danil Makarov, Peter A. Pinto, Brian Rini, Mack RoachHoward Sandler, Peter N. Schlegel, Daniel Song, Kirsten Goldberg, Richard Pazdur, Julia A. Beaver

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

PURPOSE: The following is a summary of discussion at a United States FDA (Food and Drug Administration) public workshop reviewing potential trial designs and end points to develop therapies to treat localized prostate cancer. MATERIALS AND METHODS: The workshop focused on the challenge that drug and device development to treat localized prostate cancer has been limited by the large trial sizes and lengthy timelines required to demonstrate an improvement in overall or metastasis-free survival and by the lack of agreed on alternative end points. Additionally, evolving treatment paradigms in the management of localized prostate cancer include the widespread use of active surveillance of patients with low and some intermediate risk prostate cancer, and the availability of advances in imaging and genomics. RESULTS: The workshop addressed issues related to trial design in this setting. Attendees discussed several potential novel end points such as a delay of morbidity due to radiation or prostatectomy and pathological end points such as Gleason Grade Group upgrade. CONCLUSIONS: The workshop provided an open forum for multiple stakeholder engagement to advance the development of effective treatment options for men with localized prostate cancer.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalThe Journal of urology
Volume203
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • United States Food and Drug Administration
  • drug development
  • equipment design
  • prostatic neoplasms
  • research design

ASJC Scopus subject areas

  • Urology

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    Weinstock, C., Suzman, D., Kluetz, P., Baxley, J., Viviano, C., Ibrahim, A., Jarow, J., Sridhara, R., Liu, K., Carroll, P., Eggener, S., Hu, J. C., Hussain, M., King, M., Klein, E., Kungel, T., Makarov, D., Pinto, P. A., Rini, B., ... Beaver, J. A. (2020). Development of Treatments for Localized Prostate Cancer in Patients Eligible for Active Surveillance: U.S. Food and Drug Administration Oncology Center of Excellence Public Workshop. The Journal of urology, 203(1), 115-119. https://doi.org/10.1097/JU.0000000000000532