Developmental characteristics in adult forebrain following neonatal unilateral olfactory bulbectomy

Enikö Račeková*, Judita Orendáčová, Marcela Martončiková, Tanja Zigova, Gabriela Sekerkova, Jozef Maršala

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

In this study we performed neonatal unilateral olfactory bulbectomy to determine the influence of the olfactory bulb on the development of forebrain anatomical characteristics. Histological examination was used to examine the long-term effect of the neonatal olfactory bulb removal on the rostral migratory stream general morphology in rats. BrdU-immunohistochemistry presented here provides evidence of the proliferating cells topography throughout this migratory pathway. To analyse spatial distribution of the rostral migratory stream on bulbectomized versus intact side camera lucida drawing was used. The results show that although the migratory stream anatomical pattern of bulbectomized rats was similar to the control adult ones, an open olfactory ventricle was regularly present within it. These findings indicate that neonatal bulbectomy maintains the prosencephalic region developmental pattern till adulthood.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalNeuroscience Research Communications
Volume31
Issue number1
DOIs
StatePublished - Jul 1 2002

Keywords

  • Neonatal olfactory bulbectomy
  • Olfactory ventricle
  • Rostral migratory stream

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Developmental characteristics in adult forebrain following neonatal unilateral olfactory bulbectomy'. Together they form a unique fingerprint.

Cite this