Developmental pathways: Sonic hedgehog-patched-GLI

Research output: Contribution to journalShort survey

42 Scopus citations

Abstract

Developmental pathways are networks of genes that act coordinately to establish the body plan. Disruptions of genes in one pathway can have effects in related pathways and may result in serious dysmorphogenesis or cancer. Environmental exposures can be associated with poor pregnancy outcomes, including dysmorphic offspring or children with a variety of diseases. An important goal of environmental science should be reduction of these poor outcomes. This will require an understanding of the genes affected by specific exposures and the consequence of alterations in these genes or their products, which in turn will require an understanding of the pathways critical in development. The ligand Sonic hedgehog, the receptors Patched and Smoothened, and the GLI family of transcription factors represent one such pathway. This pathway illustrates several operating principles important in the consideration of developmental consequences of environmental exposures to toxins.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalEnvironmental Health Perspectives
Volume107
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Developmental pathways
  • Developmental toxicology
  • GLI
  • Patched
  • Smoothened
  • Sonic hedgehog

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Developmental pathways: Sonic hedgehog-patched-GLI'. Together they form a unique fingerprint.

  • Cite this