Developmental regulation of a slowly-inactivating potassium conductance in rat neostriatal neurons

D. James Surmeier; Alessandro Stefani; Robert C. Foehring; S. T. Kitai

doi:10.1016/0304-3940(91)90188-Y

Developmental regulation of a slowly-inactivating potassium conductance in rat neostriatal neurons

D. James Surmeier^*, Alessandro Stefani, Robert C. Foehring, S. T. Kitai

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

In late embryonic and early post-natal rat neostriatal neurons, the voltage-dependent potassium currents activated by depolarization are largely attributable to a rapidly inactivating A-current and a delayed rectifier current. Over the first 4 weeks of post-natal life, a third potassium current emerges in most cells. This slowly inactivating conductance is distinct from the A-current and delayed rectifier in voltage-dependence, kinetics and pharmacology. The properties of this conductance suggest that it may be of central importance to the integrative behavior of neostriatal neurons by controlling such features as first spike latency and interspike interval.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Neuroscience Letters
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90188-Y
State	Published - Jan 14 1991

Funding

This work was supported by USPHS Grant NS 26473 to S.T.K. and D.J.S. and NS 20702 to S.T.K.

Keywords

A-current
D-current
Development
Neostriatum
Potassium current

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90188-Y

Cite this

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title = "Developmental regulation of a slowly-inactivating potassium conductance in rat neostriatal neurons",

abstract = "In late embryonic and early post-natal rat neostriatal neurons, the voltage-dependent potassium currents activated by depolarization are largely attributable to a rapidly inactivating A-current and a delayed rectifier current. Over the first 4 weeks of post-natal life, a third potassium current emerges in most cells. This slowly inactivating conductance is distinct from the A-current and delayed rectifier in voltage-dependence, kinetics and pharmacology. The properties of this conductance suggest that it may be of central importance to the integrative behavior of neostriatal neurons by controlling such features as first spike latency and interspike interval.",

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AU - Foehring, Robert C.

AU - Kitai, S. T.

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N2 - In late embryonic and early post-natal rat neostriatal neurons, the voltage-dependent potassium currents activated by depolarization are largely attributable to a rapidly inactivating A-current and a delayed rectifier current. Over the first 4 weeks of post-natal life, a third potassium current emerges in most cells. This slowly inactivating conductance is distinct from the A-current and delayed rectifier in voltage-dependence, kinetics and pharmacology. The properties of this conductance suggest that it may be of central importance to the integrative behavior of neostriatal neurons by controlling such features as first spike latency and interspike interval.

AB - In late embryonic and early post-natal rat neostriatal neurons, the voltage-dependent potassium currents activated by depolarization are largely attributable to a rapidly inactivating A-current and a delayed rectifier current. Over the first 4 weeks of post-natal life, a third potassium current emerges in most cells. This slowly inactivating conductance is distinct from the A-current and delayed rectifier in voltage-dependence, kinetics and pharmacology. The properties of this conductance suggest that it may be of central importance to the integrative behavior of neostriatal neurons by controlling such features as first spike latency and interspike interval.

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Developmental regulation of a slowly-inactivating potassium conductance in rat neostriatal neurons

Abstract

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Keywords

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