Developmental regulation of a slowly-inactivating potassium conductance in rat neostriatal neurons

D. James Surmeier*, Alessandro Stefani, Robert C. Foehring, S. T. Kitai

*Corresponding author for this work

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

In late embryonic and early post-natal rat neostriatal neurons, the voltage-dependent potassium currents activated by depolarization are largely attributable to a rapidly inactivating A-current and a delayed rectifier current. Over the first 4 weeks of post-natal life, a third potassium current emerges in most cells. This slowly inactivating conductance is distinct from the A-current and delayed rectifier in voltage-dependence, kinetics and pharmacology. The properties of this conductance suggest that it may be of central importance to the integrative behavior of neostriatal neurons by controlling such features as first spike latency and interspike interval.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalNeuroscience Letters
Volume122
Issue number1
DOIs
StatePublished - Jan 14 1991

Keywords

  • A-current
  • D-current
  • Development
  • Neostriatum
  • Potassium current

ASJC Scopus subject areas

  • Neuroscience(all)

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