Developmental trajectories and correlates of sensory processing in young boys with fragile X syndrome

Grace T. Baranek, Jane E. Roberts, Fabian J. David, John Sideris, Penny L. Mirrett, Deborah D. Hatton, Donald B. Bailey

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Background and Purpose: No longitudinal study on sensory processing in children with fragile X syndrome (FXS) exists. This study examined developmental trajectories and correlates of sensory processing from infancy through preschool years in 13 boys with FXS. Method: Participants were assessed using observational and parent-report measures 2-6 times between 9 and 54 months of age. Results: Over time, an increasing proportion of boys displayed sensory processing that differed significantly from test norms. Observational measures were more sensitive than parent-reports early in infancy. Age and developmental quotient significantly predicted levels of hyporesponsiveness; there was a trend for hyperresponsiveness to increase with age. Baseline physiological and biological measures were not predictive. Conclusions: Sensory processing problems are observable early and grow increasingly problematic from infancy through the preschool ages. Early identification and intervention may attenuate long-term difficulties for children with FXS.

Original languageEnglish (US)
Pages (from-to)79-98
Number of pages20
JournalPhysical and Occupational Therapy in Pediatrics
Issue number1
StatePublished - Jan 4 2008


  • Developmental disabilities
  • Fragile X
  • Infant development
  • Sensory processing and integration

ASJC Scopus subject areas

  • Occupational Therapy
  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Pediatrics, Perinatology, and Child Health


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