Device based left ventricular shape change: Validation of conductance technology in shape changed hearts

Masami Takagaki; Patrick M. McCarthy; Raymond Dessoffy; Yoshie Ochiai; Kazuyoshi Doi; Michael W. Howard; Jianxin Qin; Hua Yang; Takahiro Shiota; Jason Connor; Kiyotaka Fukamachi

doi:10.1097/00002480-200205000-00012

Device based left ventricular shape change: Validation of conductance technology in shape changed hearts

Masami Takagaki, Patrick M. McCarthy^*, Raymond Dessoffy, Yoshie Ochiai, Kazuyoshi Doi, Michael W. Howard, Jianxin Qin, Hua Yang, Takahiro Shiota, Jason Connor, Kiyotaka Fukamachi

^*Corresponding author for this work

Surgery, Cardiac Surgery Division

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We have reported that device based left ventricular (LV) shape change, accomplished by Myosplint, improved LV systolic function by three-dimensional echocardiography (3-D echo). However, evaluation of this device using the pressure-volume relationship is still important. This study was conducted to validate the use of conductance technology for this evaluation in shape-changed hearts. An ex vivo study using excised ovine hearts (n = 11) and an in vivo study using a canine pacing-induced heart failure model (n = 11) were performed. Three Myosplints were implanted. Before and after the shape changes, volumes measured by a conductance catheter were compared with volumes measured by the amount of saline in the ex vivo study or by 3-D echo in the in vivo study. The conductance volumes were linearly correlated with the saline volumes (r² = 0.961 ± 0.046; p < 0.0001) in the ex vivo study and with 3-D echo volumes (r² = 0.757 ± 0.220; p < 0.0001) in the in vivo study. The conductance volumes were linearly correlated with LV volumes even in the shape-changed hearts. This technology can be used to evaluate pressure-volume loops in the shape-changed hearts as long as the conductance volume is calibrated by a reliable method.

Original language	English (US)
Pages (from-to)	268-271
Number of pages	4
Journal	ASAIO Journal
Volume	48
Issue number	3
DOIs	https://doi.org/10.1097/00002480-200205000-00012
State	Published - Jan 1 2002

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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title = "Device based left ventricular shape change: Validation of conductance technology in shape changed hearts",

abstract = "We have reported that device based left ventricular (LV) shape change, accomplished by Myosplint, improved LV systolic function by three-dimensional echocardiography (3-D echo). However, evaluation of this device using the pressure-volume relationship is still important. This study was conducted to validate the use of conductance technology for this evaluation in shape-changed hearts. An ex vivo study using excised ovine hearts (n = 11) and an in vivo study using a canine pacing-induced heart failure model (n = 11) were performed. Three Myosplints were implanted. Before and after the shape changes, volumes measured by a conductance catheter were compared with volumes measured by the amount of saline in the ex vivo study or by 3-D echo in the in vivo study. The conductance volumes were linearly correlated with the saline volumes (r2 = 0.961 ± 0.046; p < 0.0001) in the ex vivo study and with 3-D echo volumes (r2 = 0.757 ± 0.220; p < 0.0001) in the in vivo study. The conductance volumes were linearly correlated with LV volumes even in the shape-changed hearts. This technology can be used to evaluate pressure-volume loops in the shape-changed hearts as long as the conductance volume is calibrated by a reliable method.",

author = "Masami Takagaki and McCarthy, {Patrick M.} and Raymond Dessoffy and Yoshie Ochiai and Kazuyoshi Doi and Howard, {Michael W.} and Jianxin Qin and Hua Yang and Takahiro Shiota and Jason Connor and Kiyotaka Fukamachi",

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T2 - Validation of conductance technology in shape changed hearts

AU - Takagaki, Masami

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AU - Dessoffy, Raymond

AU - Ochiai, Yoshie

AU - Doi, Kazuyoshi

AU - Howard, Michael W.

AU - Qin, Jianxin

AU - Yang, Hua

AU - Shiota, Takahiro

AU - Connor, Jason

AU - Fukamachi, Kiyotaka

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N2 - We have reported that device based left ventricular (LV) shape change, accomplished by Myosplint, improved LV systolic function by three-dimensional echocardiography (3-D echo). However, evaluation of this device using the pressure-volume relationship is still important. This study was conducted to validate the use of conductance technology for this evaluation in shape-changed hearts. An ex vivo study using excised ovine hearts (n = 11) and an in vivo study using a canine pacing-induced heart failure model (n = 11) were performed. Three Myosplints were implanted. Before and after the shape changes, volumes measured by a conductance catheter were compared with volumes measured by the amount of saline in the ex vivo study or by 3-D echo in the in vivo study. The conductance volumes were linearly correlated with the saline volumes (r2 = 0.961 ± 0.046; p < 0.0001) in the ex vivo study and with 3-D echo volumes (r2 = 0.757 ± 0.220; p < 0.0001) in the in vivo study. The conductance volumes were linearly correlated with LV volumes even in the shape-changed hearts. This technology can be used to evaluate pressure-volume loops in the shape-changed hearts as long as the conductance volume is calibrated by a reliable method.

AB - We have reported that device based left ventricular (LV) shape change, accomplished by Myosplint, improved LV systolic function by three-dimensional echocardiography (3-D echo). However, evaluation of this device using the pressure-volume relationship is still important. This study was conducted to validate the use of conductance technology for this evaluation in shape-changed hearts. An ex vivo study using excised ovine hearts (n = 11) and an in vivo study using a canine pacing-induced heart failure model (n = 11) were performed. Three Myosplints were implanted. Before and after the shape changes, volumes measured by a conductance catheter were compared with volumes measured by the amount of saline in the ex vivo study or by 3-D echo in the in vivo study. The conductance volumes were linearly correlated with the saline volumes (r2 = 0.961 ± 0.046; p < 0.0001) in the ex vivo study and with 3-D echo volumes (r2 = 0.757 ± 0.220; p < 0.0001) in the in vivo study. The conductance volumes were linearly correlated with LV volumes even in the shape-changed hearts. This technology can be used to evaluate pressure-volume loops in the shape-changed hearts as long as the conductance volume is calibrated by a reliable method.

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Device based left ventricular shape change: Validation of conductance technology in shape changed hearts

Abstract

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