Device based left ventricular shape change: Validation of conductance technology in shape changed hearts

Masami Takagaki, Patrick M. McCarthy*, Raymond Dessoffy, Yoshie Ochiai, Kazuyoshi Doi, Michael W. Howard, Jianxin Qin, Hua Yang, Takahiro Shiota, Jason Connor, Kiyotaka Fukamachi

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We have reported that device based left ventricular (LV) shape change, accomplished by Myosplint, improved LV systolic function by three-dimensional echocardiography (3-D echo). However, evaluation of this device using the pressure-volume relationship is still important. This study was conducted to validate the use of conductance technology for this evaluation in shape-changed hearts. An ex vivo study using excised ovine hearts (n = 11) and an in vivo study using a canine pacing-induced heart failure model (n = 11) were performed. Three Myosplints were implanted. Before and after the shape changes, volumes measured by a conductance catheter were compared with volumes measured by the amount of saline in the ex vivo study or by 3-D echo in the in vivo study. The conductance volumes were linearly correlated with the saline volumes (r2 = 0.961 ± 0.046; p < 0.0001) in the ex vivo study and with 3-D echo volumes (r2 = 0.757 ± 0.220; p < 0.0001) in the in vivo study. The conductance volumes were linearly correlated with LV volumes even in the shape-changed hearts. This technology can be used to evaluate pressure-volume loops in the shape-changed hearts as long as the conductance volume is calibrated by a reliable method.

Original languageEnglish (US)
Pages (from-to)268-271
Number of pages4
JournalASAIO Journal
Volume48
Issue number3
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Takagaki, M., McCarthy, P. M., Dessoffy, R., Ochiai, Y., Doi, K., Howard, M. W., Qin, J., Yang, H., Shiota, T., Connor, J., & Fukamachi, K. (2002). Device based left ventricular shape change: Validation of conductance technology in shape changed hearts. ASAIO Journal, 48(3), 268-271. https://doi.org/10.1097/00002480-200205000-00012