Serial positron emission tomography scans with [18F]fluorodeoxyglucose (FDG) were acquired from 3 patients with malignant gliomas before and after 24 hours of dexamethasone administration (a total of 40 mg administered intravenously over 24 hours). Peak FDG uptake by the tumor decreased 10 to 20% in the posttreatment scans. The data suggest that at least some of the beneficial effects of dexamethasone on the signs and symptoms of tumor-related increased intracranial pressure might relate to a direct acute effect on glucose metabolism.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology