Dexamethasone and cyclosporin a suppress mast cell-leukocyte cytokine cascades by multiple mechanisms

Barry K. Wershil*, Glenn T. Furuta, Jackie A. Lavigne, Anjona Roy Choudhury, Zhen S. Wang, Stephen J. Galli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere with the pathogenesis IgE-, mast-cell-, and cytokine-dependent inflammatory reactions: Suppression of the IgE-dependent increase in tumor necrosis factor (TNF)-a mRN A by mast cells, inhibition of the IgE-dependent production of TNF-a protein by mast cells, and diminution of the responsiveness of target cells to TNF-a. Our findings in mice raise the possibility that similar actions of these agents in humans may account for some of the clinical efficacy of corticosteroids and cyclosporin A in allergic diseases.

Original languageEnglish (US)
Pages (from-to)323-324
Number of pages2
JournalInternational archives of allergy and immunology
Volume107
Issue number1-3
DOIs
StatePublished - 1995

Keywords

  • Cutaneous
  • Cyclosporin A
  • Cytokines
  • Dexamethasone
  • Histamine
  • Inflammation
  • Mast cells
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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