Di-(2-ethylhexyl)phthalate: An industrial plasticizer induces hypolipidemia and enhances hepatic catalase and carnitine acetyltransferase activities in rats and mice

J. K. Reddy*, D. E. Moody, D. L. Azarnoff, M. S. Rao

*Corresponding author for this work

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

Di-(2-ethylhexyl)phthalate (DOP), a plasticizer, when administered to rats and mice at a dietary concentration of 0.5 percent, 2 percent or 4 percent, caused a substantial reduction in serum cholesterol and triglyceride levels. The hypocholesterolemic and hypotriglyceridemic effects were more pronounced in rats fed DOP at 2 and 4 percent level than in mice. The hypolipidemic effect of this compound is associated with marked hepatomegaly in both species. The liver cells of both rats and mice fed this plasticizer for 1-4 weeks, revealed a considerable increase in peroxisome population. The elevations of hepatic catalase and carnitine acetyltransferase activities appeared to parallel the peroxisome proliferation induced by this compound. The hypolipidemic and peroxisome proliferative effects of this compound strongly suggest that all peroxisome proliferators possess hypolipidemic properties.

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalLife Sciences
Volume18
Issue number9
DOIs
StatePublished - May 1 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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