Diabetes mellitus

William L Lowe Jr*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes results from a deficiency of insulin action secondary to a combination of insulin resistance and relative β-cell dysfunction. Familial clustering of type 1 and 2 diabetes has suggested a genetic contribution to the etiology of the diseases, but monozygotic twin and other studies have indicated that environmental factors also contribute to their etiology. Although relatively rare monogenic forms of diabetes have been described, type 1 and 2 diabetes are, in general, complex, polygenic diseases.

Original languageEnglish (US)
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages308-318
Number of pages11
ISBN (Print)9781588292025
DOIs
StatePublished - Dec 1 2006

Fingerprint

Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Diabetes Mellitus
Twin Studies
Monozygotic Twins
Insulin-Secreting Cells
Hyperglycemia
Cluster Analysis
Insulin Resistance
Fasting
Insulin

Keywords

  • Autoimmunity
  • genetics
  • insulin
  • major histocom-patibility complex
  • maturity onset diabetes of the young
  • mitochondria
  • peroxisome proliferator-activated receptor-γ
  • sulfonylurea receptor
  • type 1 diabetes
  • type 2 diabetes
  • Wolfram syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lowe Jr, W. L. (2006). Diabetes mellitus. In Principles of Molecular Medicine (pp. 308-318). Humana Press. https://doi.org/10.1007/978-1-59259-963-9_32
Lowe Jr, William L. / Diabetes mellitus. Principles of Molecular Medicine. Humana Press, 2006. pp. 308-318
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Lowe Jr, WL 2006, Diabetes mellitus. in Principles of Molecular Medicine. Humana Press, pp. 308-318. https://doi.org/10.1007/978-1-59259-963-9_32

Diabetes mellitus. / Lowe Jr, William L.

Principles of Molecular Medicine. Humana Press, 2006. p. 308-318.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Lowe Jr WL. Diabetes mellitus. In Principles of Molecular Medicine. Humana Press. 2006. p. 308-318 https://doi.org/10.1007/978-1-59259-963-9_32