Diabetes mellitus

William L Lowe Jr

doi:10.1007/978-1-59259-963-9_32

Diabetes mellitus

William L Lowe Jr^*

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes results from a deficiency of insulin action secondary to a combination of insulin resistance and relative β-cell dysfunction. Familial clustering of type 1 and 2 diabetes has suggested a genetic contribution to the etiology of the diseases, but monozygotic twin and other studies have indicated that environmental factors also contribute to their etiology. Although relatively rare monogenic forms of diabetes have been described, type 1 and 2 diabetes are, in general, complex, polygenic diseases.

Original language	English (US)
Title of host publication	Principles of Molecular Medicine
Publisher	Humana Press
Pages	308-318
Number of pages	11
ISBN (Print)	9781588292025
DOIs	https://doi.org/10.1007/978-1-59259-963-9_32
State	Published - Dec 1 2006

Keywords

Autoimmunity
genetics
insulin
major histocom-patibility complex
maturity onset diabetes of the young
mitochondria
peroxisome proliferator-activated receptor-γ
sulfonylurea receptor
type 1 diabetes
type 2 diabetes
Wolfram syndrome

ASJC Scopus subject areas

Medicine(all)

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