Abstract
Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes results from a deficiency of insulin action secondary to a combination of insulin resistance and relative β-cell dysfunction. Familial clustering of type 1 and 2 diabetes has suggested a genetic contribution to the etiology of the diseases, but monozygotic twin and other studies have indicated that environmental factors also contribute to their etiology. Although relatively rare monogenic forms of diabetes have been described, type 1 and 2 diabetes are, in general, complex, polygenic diseases.
| Original language | English (US) |
|---|---|
| Title of host publication | Principles of Molecular Medicine |
| Publisher | Humana Press |
| Pages | 308-318 |
| Number of pages | 11 |
| ISBN (Print) | 9781588292025 |
| DOIs | |
| State | Published - Dec 1 2006 |
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Keywords
- Autoimmunity
- genetics
- insulin
- major histocom-patibility complex
- maturity onset diabetes of the young
- mitochondria
- peroxisome proliferator-activated receptor-γ
- sulfonylurea receptor
- type 1 diabetes
- type 2 diabetes
- Wolfram syndrome
ASJC Scopus subject areas
- Medicine(all)
Cite this
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Diabetes mellitus. / Lowe Jr, William L.
Principles of Molecular Medicine. Humana Press, 2006. p. 308-318.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Diabetes mellitus
AU - Lowe Jr, William L
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes results from a deficiency of insulin action secondary to a combination of insulin resistance and relative β-cell dysfunction. Familial clustering of type 1 and 2 diabetes has suggested a genetic contribution to the etiology of the diseases, but monozygotic twin and other studies have indicated that environmental factors also contribute to their etiology. Although relatively rare monogenic forms of diabetes have been described, type 1 and 2 diabetes are, in general, complex, polygenic diseases.
AB - Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes results from a deficiency of insulin action secondary to a combination of insulin resistance and relative β-cell dysfunction. Familial clustering of type 1 and 2 diabetes has suggested a genetic contribution to the etiology of the diseases, but monozygotic twin and other studies have indicated that environmental factors also contribute to their etiology. Although relatively rare monogenic forms of diabetes have been described, type 1 and 2 diabetes are, in general, complex, polygenic diseases.
KW - Autoimmunity
KW - genetics
KW - insulin
KW - major histocom-patibility complex
KW - maturity onset diabetes of the young
KW - mitochondria
KW - peroxisome proliferator-activated receptor-γ
KW - sulfonylurea receptor
KW - type 1 diabetes
KW - type 2 diabetes
KW - Wolfram syndrome
UR - http://www.scopus.com/inward/record.url?scp=84891471836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891471836&partnerID=8YFLogxK
U2 - 10.1007/978-1-59259-963-9_32
DO - 10.1007/978-1-59259-963-9_32
M3 - Chapter
AN - SCOPUS:84891471836
SN - 9781588292025
SP - 308
EP - 318
BT - Principles of Molecular Medicine
PB - Humana Press
ER -