Diabetes screening outcomes in youth presenting for paediatric weight management: A report of the Paediatric Obesity Weight Evaluation Registry

Seema Kumar; Eileen King; Helen J. Binns; Amy Christison; Suzanne E. Cuda; Jennifer K. Yee; Madeline Joseph; Shelley Kirk

doi:10.1111/ijpo.13102

Diabetes screening outcomes in youth presenting for paediatric weight management: A report of the Paediatric Obesity Weight Evaluation Registry

Seema Kumar^*, Eileen King, Helen J. Binns, Amy Christison, Suzanne E. Cuda, Jennifer K. Yee, Madeline Joseph, Shelley Kirk

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Rising prevalence of obesity has led to increased rates of prediabetes and diabetes mellitus (DM) in children. This study compares rates of prediabetes and diabetes using two recommended screening tests (fasting plasma glucose [FPG] and haemoglobin A1c [HbA1c]). Study Design: Data were collected prospectively from 37 multi-component paediatric weight management programs in POWER (Paediatric Obesity Weight Evaluation Registry). Results: For this study, 3962 children with obesity without a known diagnosis of DM at presentation and for whom concurrent measurement of FPG and HbA1c were available were evaluated (median age 12.0 years [interquartile range, IQR 9.8, 14.6]; 48% males; median body mass index 95th percentile [%BMIp95] 134% [IQR 120, 151]). Notably, 10.7% had prediabetes based on FPG criteria (100–125 mg/dL), 18.6% had prediabetes based on HbA1c criteria (5.7%–6.4%), 0.9% had DM by FPG abnormality (≥126 mg/dL) and 1.1% had DM by HbA1c abnormality (≥6.5%). Discordance between the tests was observed for youth in both age groups (10–18 years [n = 2915] and age 2–9 years [n = 1047]). Conclusion: There is discordance between FPG and HbA1c for the diagnosis of prediabetes and DM in youth with obesity. Further studies are needed to understand the predictive capability of these tests for development of DM (in those diagnosed with prediabetes) and cardiometabolic risk.

Original language	English (US)
Article number	e13102
Journal	Pediatric Obesity
Volume	19
Issue number	4
DOIs	https://doi.org/10.1111/ijpo.13102
State	Published - Apr 2024

Funding

The authors are thankful to the many patients and family members who participate in POWER. The authors gratefully acknowledge the administrative support provided by program coordinator, Deborah Wolff, BS and technical support provided by regulatory specialist, Katy Fischesser, MS, CCRP, with the Heart Institute Research Core, Cincinnati Children's Hospital Medical Center (CCHMC). In addition, database programmer, Jennifer Andringa, BA; data specialist, Carolyn Powers, BS, RD, CCDM; SAS programmer, Yanhong Liu; and manager, Rachel Akers, MPH, CCDM, with the POWER Data Coordinating Center in the Division of Epidemiology and Biostatistics, CCHMC, have made important contributions to the management and analysis of the POWER data.

Keywords

diabetes mellitus
glucose
haemoglobin A1C
paediatric obesity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Health Policy
Nutrition and Dietetics
Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/ijpo.13102

Cite this

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title = "Diabetes screening outcomes in youth presenting for paediatric weight management: A report of the Paediatric Obesity Weight Evaluation Registry",

abstract = "Objective: Rising prevalence of obesity has led to increased rates of prediabetes and diabetes mellitus (DM) in children. This study compares rates of prediabetes and diabetes using two recommended screening tests (fasting plasma glucose [FPG] and haemoglobin A1c [HbA1c]). Study Design: Data were collected prospectively from 37 multi-component paediatric weight management programs in POWER (Paediatric Obesity Weight Evaluation Registry). Results: For this study, 3962 children with obesity without a known diagnosis of DM at presentation and for whom concurrent measurement of FPG and HbA1c were available were evaluated (median age 12.0 years [interquartile range, IQR 9.8, 14.6]; 48\% males; median body mass index 95th percentile [\%BMIp95] 134\% [IQR 120, 151]). Notably, 10.7\% had prediabetes based on FPG criteria (100–125 mg/dL), 18.6\% had prediabetes based on HbA1c criteria (5.7\%–6.4\%), 0.9\% had DM by FPG abnormality (≥126 mg/dL) and 1.1\% had DM by HbA1c abnormality (≥6.5\%). Discordance between the tests was observed for youth in both age groups (10–18 years [n = 2915] and age 2–9 years [n = 1047]). Conclusion: There is discordance between FPG and HbA1c for the diagnosis of prediabetes and DM in youth with obesity. Further studies are needed to understand the predictive capability of these tests for development of DM (in those diagnosed with prediabetes) and cardiometabolic risk.",

keywords = "diabetes mellitus, glucose, haemoglobin A1C, paediatric obesity",

author = "Seema Kumar and Eileen King and Binns, \{Helen J.\} and Amy Christison and Cuda, \{Suzanne E.\} and Yee, \{Jennifer K.\} and Madeline Joseph and Shelley Kirk",

note = "Publisher Copyright: {\textcopyright} 2024 World Obesity Federation.",

year = "2024",

month = apr,

doi = "10.1111/ijpo.13102",

language = "English (US)",

volume = "19",

journal = "Pediatric Obesity",

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T2 - A report of the Paediatric Obesity Weight Evaluation Registry

AU - Kumar, Seema

AU - King, Eileen

AU - Binns, Helen J.

AU - Christison, Amy

AU - Cuda, Suzanne E.

AU - Yee, Jennifer K.

AU - Joseph, Madeline

AU - Kirk, Shelley

PY - 2024/4

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N2 - Objective: Rising prevalence of obesity has led to increased rates of prediabetes and diabetes mellitus (DM) in children. This study compares rates of prediabetes and diabetes using two recommended screening tests (fasting plasma glucose [FPG] and haemoglobin A1c [HbA1c]). Study Design: Data were collected prospectively from 37 multi-component paediatric weight management programs in POWER (Paediatric Obesity Weight Evaluation Registry). Results: For this study, 3962 children with obesity without a known diagnosis of DM at presentation and for whom concurrent measurement of FPG and HbA1c were available were evaluated (median age 12.0 years [interquartile range, IQR 9.8, 14.6]; 48% males; median body mass index 95th percentile [%BMIp95] 134% [IQR 120, 151]). Notably, 10.7% had prediabetes based on FPG criteria (100–125 mg/dL), 18.6% had prediabetes based on HbA1c criteria (5.7%–6.4%), 0.9% had DM by FPG abnormality (≥126 mg/dL) and 1.1% had DM by HbA1c abnormality (≥6.5%). Discordance between the tests was observed for youth in both age groups (10–18 years [n = 2915] and age 2–9 years [n = 1047]). Conclusion: There is discordance between FPG and HbA1c for the diagnosis of prediabetes and DM in youth with obesity. Further studies are needed to understand the predictive capability of these tests for development of DM (in those diagnosed with prediabetes) and cardiometabolic risk.

AB - Objective: Rising prevalence of obesity has led to increased rates of prediabetes and diabetes mellitus (DM) in children. This study compares rates of prediabetes and diabetes using two recommended screening tests (fasting plasma glucose [FPG] and haemoglobin A1c [HbA1c]). Study Design: Data were collected prospectively from 37 multi-component paediatric weight management programs in POWER (Paediatric Obesity Weight Evaluation Registry). Results: For this study, 3962 children with obesity without a known diagnosis of DM at presentation and for whom concurrent measurement of FPG and HbA1c were available were evaluated (median age 12.0 years [interquartile range, IQR 9.8, 14.6]; 48% males; median body mass index 95th percentile [%BMIp95] 134% [IQR 120, 151]). Notably, 10.7% had prediabetes based on FPG criteria (100–125 mg/dL), 18.6% had prediabetes based on HbA1c criteria (5.7%–6.4%), 0.9% had DM by FPG abnormality (≥126 mg/dL) and 1.1% had DM by HbA1c abnormality (≥6.5%). Discordance between the tests was observed for youth in both age groups (10–18 years [n = 2915] and age 2–9 years [n = 1047]). Conclusion: There is discordance between FPG and HbA1c for the diagnosis of prediabetes and DM in youth with obesity. Further studies are needed to understand the predictive capability of these tests for development of DM (in those diagnosed with prediabetes) and cardiometabolic risk.

KW - diabetes mellitus

KW - glucose

KW - haemoglobin A1C

KW - paediatric obesity

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JO - Pediatric Obesity

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ER -

Diabetes screening outcomes in youth presenting for paediatric weight management: A report of the Paediatric Obesity Weight Evaluation Registry

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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