Diabetes symptoms predictors of health-related quality of life in adolescents and young adults with type 1 or type 2 diabetes

The Pediatric Quality Of Life Inventory™ 3.2 Diabetes Module Testing Study Consortium

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: The objective was to investigate the patient-reported diabetes symptoms predictors of generic health-related quality of life (HRQOL) in adolescents and young adults (AYA) with type 1 or type 2 diabetes. Methods: The 15-item PedsQL™ 3.2 Diabetes Module Diabetes Symptoms Summary Score and PedsQL™ 4.0 Generic Core Scales were completed in a 10-site national field test study by 513 AYA ages 13–25 years with type 1 (n = 424) or type 2 (n = 89) diabetes. Diabetes symptoms were tested for bivariate and multivariate linear associations with generic HRQOL. Results: Diabetes symptoms were associated with decreased HRQOL in bivariate analyses. In predictive analytics models utilizing hierarchical multiple regression analyses controlling for relevant demographic and clinical covariates, diabetes symptoms accounted for 38 and 39% of the variance in patient-reported generic HRQOL for type 1 and type 2 diabetes, respectively, reflecting large effect sizes. The diabetes symptoms facets hyperglycemia symptoms, hypoglycemia symptoms, and nonspecific diabetes symptoms individually accounted for a significant percentage of the variance in separate exploratory predictive analytics models after controlling for demographic and clinical covariates, with small-to-large effect sizes. Conclusions: Diabetes symptoms are potentially modifiable predictors of generic HRQOL in AYA with diabetes. Identifying specific diabetes symptoms or symptoms facets that are the most important predictors from the patient perspective facilitates a patient-centered approach in clinical research, clinical trials, and practice designed to enhance overall generic HRQOL in AYA with diabetes.

Original languageEnglish (US)
Pages (from-to)2295-2303
Number of pages9
JournalQuality of Life Research
Volume27
Issue number9
DOIs
StatePublished - Sep 1 2018

Fingerprint

Type 2 Diabetes Mellitus
Young Adult
Quality of Life
Demography
Type 1 Diabetes Mellitus
Hypoglycemia
Hyperglycemia
Regression Analysis
Clinical Trials
Research

Keywords

  • Diabetes
  • Health-related quality of life
  • Patient-reported outcomes
  • Pediatrics
  • PedsQL
  • Symptoms
  • Type 1 diabetes
  • Type 2 diabetes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

The Pediatric Quality Of Life Inventory™ 3.2 Diabetes Module Testing Study Consortium. / Diabetes symptoms predictors of health-related quality of life in adolescents and young adults with type 1 or type 2 diabetes. In: Quality of Life Research. 2018 ; Vol. 27, No. 9. pp. 2295-2303.
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title = "Diabetes symptoms predictors of health-related quality of life in adolescents and young adults with type 1 or type 2 diabetes",
abstract = "Objectives: The objective was to investigate the patient-reported diabetes symptoms predictors of generic health-related quality of life (HRQOL) in adolescents and young adults (AYA) with type 1 or type 2 diabetes. Methods: The 15-item PedsQL™ 3.2 Diabetes Module Diabetes Symptoms Summary Score and PedsQL™ 4.0 Generic Core Scales were completed in a 10-site national field test study by 513 AYA ages 13–25 years with type 1 (n = 424) or type 2 (n = 89) diabetes. Diabetes symptoms were tested for bivariate and multivariate linear associations with generic HRQOL. Results: Diabetes symptoms were associated with decreased HRQOL in bivariate analyses. In predictive analytics models utilizing hierarchical multiple regression analyses controlling for relevant demographic and clinical covariates, diabetes symptoms accounted for 38 and 39{\%} of the variance in patient-reported generic HRQOL for type 1 and type 2 diabetes, respectively, reflecting large effect sizes. The diabetes symptoms facets hyperglycemia symptoms, hypoglycemia symptoms, and nonspecific diabetes symptoms individually accounted for a significant percentage of the variance in separate exploratory predictive analytics models after controlling for demographic and clinical covariates, with small-to-large effect sizes. Conclusions: Diabetes symptoms are potentially modifiable predictors of generic HRQOL in AYA with diabetes. Identifying specific diabetes symptoms or symptoms facets that are the most important predictors from the patient perspective facilitates a patient-centered approach in clinical research, clinical trials, and practice designed to enhance overall generic HRQOL in AYA with diabetes.",
keywords = "Diabetes, Health-related quality of life, Patient-reported outcomes, Pediatrics, PedsQL, Symptoms, Type 1 diabetes, Type 2 diabetes",
author = "{The Pediatric Quality Of Life Inventory™ 3.2 Diabetes Module Testing Study Consortium} and Varni, {James W.} and Delamater, {Alan M.} and Hood, {Korey K.} and Raymond, {Jennifer K.} and Driscoll, {Kimberly A.} and Wong, {Jenise C.} and Saleh Adi and Yi-Frazier, {Joyce P.} and Grishman, {Ellen K.} and Faith, {Melissa A.} and Corathers, {Sarah D.} and Kichler, {Jessica C.} and Miller, {Jennifer L} and Doskey, {Elena M.} and Aguirre, {Vincent P.} and Heffer, {Robert W.} and Wilson, {Don P.} and Varni, {James W.} and Chang, {Nancy T.}",
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The Pediatric Quality Of Life Inventory™ 3.2 Diabetes Module Testing Study Consortium 2018, 'Diabetes symptoms predictors of health-related quality of life in adolescents and young adults with type 1 or type 2 diabetes', Quality of Life Research, vol. 27, no. 9, pp. 2295-2303. https://doi.org/10.1007/s11136-018-1884-6

Diabetes symptoms predictors of health-related quality of life in adolescents and young adults with type 1 or type 2 diabetes. / The Pediatric Quality Of Life Inventory™ 3.2 Diabetes Module Testing Study Consortium.

In: Quality of Life Research, Vol. 27, No. 9, 01.09.2018, p. 2295-2303.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diabetes symptoms predictors of health-related quality of life in adolescents and young adults with type 1 or type 2 diabetes

AU - The Pediatric Quality Of Life Inventory™ 3.2 Diabetes Module Testing Study Consortium

AU - Varni, James W.

AU - Delamater, Alan M.

AU - Hood, Korey K.

AU - Raymond, Jennifer K.

AU - Driscoll, Kimberly A.

AU - Wong, Jenise C.

AU - Adi, Saleh

AU - Yi-Frazier, Joyce P.

AU - Grishman, Ellen K.

AU - Faith, Melissa A.

AU - Corathers, Sarah D.

AU - Kichler, Jessica C.

AU - Miller, Jennifer L

AU - Doskey, Elena M.

AU - Aguirre, Vincent P.

AU - Heffer, Robert W.

AU - Wilson, Don P.

AU - Varni, James W.

AU - Chang, Nancy T.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objectives: The objective was to investigate the patient-reported diabetes symptoms predictors of generic health-related quality of life (HRQOL) in adolescents and young adults (AYA) with type 1 or type 2 diabetes. Methods: The 15-item PedsQL™ 3.2 Diabetes Module Diabetes Symptoms Summary Score and PedsQL™ 4.0 Generic Core Scales were completed in a 10-site national field test study by 513 AYA ages 13–25 years with type 1 (n = 424) or type 2 (n = 89) diabetes. Diabetes symptoms were tested for bivariate and multivariate linear associations with generic HRQOL. Results: Diabetes symptoms were associated with decreased HRQOL in bivariate analyses. In predictive analytics models utilizing hierarchical multiple regression analyses controlling for relevant demographic and clinical covariates, diabetes symptoms accounted for 38 and 39% of the variance in patient-reported generic HRQOL for type 1 and type 2 diabetes, respectively, reflecting large effect sizes. The diabetes symptoms facets hyperglycemia symptoms, hypoglycemia symptoms, and nonspecific diabetes symptoms individually accounted for a significant percentage of the variance in separate exploratory predictive analytics models after controlling for demographic and clinical covariates, with small-to-large effect sizes. Conclusions: Diabetes symptoms are potentially modifiable predictors of generic HRQOL in AYA with diabetes. Identifying specific diabetes symptoms or symptoms facets that are the most important predictors from the patient perspective facilitates a patient-centered approach in clinical research, clinical trials, and practice designed to enhance overall generic HRQOL in AYA with diabetes.

AB - Objectives: The objective was to investigate the patient-reported diabetes symptoms predictors of generic health-related quality of life (HRQOL) in adolescents and young adults (AYA) with type 1 or type 2 diabetes. Methods: The 15-item PedsQL™ 3.2 Diabetes Module Diabetes Symptoms Summary Score and PedsQL™ 4.0 Generic Core Scales were completed in a 10-site national field test study by 513 AYA ages 13–25 years with type 1 (n = 424) or type 2 (n = 89) diabetes. Diabetes symptoms were tested for bivariate and multivariate linear associations with generic HRQOL. Results: Diabetes symptoms were associated with decreased HRQOL in bivariate analyses. In predictive analytics models utilizing hierarchical multiple regression analyses controlling for relevant demographic and clinical covariates, diabetes symptoms accounted for 38 and 39% of the variance in patient-reported generic HRQOL for type 1 and type 2 diabetes, respectively, reflecting large effect sizes. The diabetes symptoms facets hyperglycemia symptoms, hypoglycemia symptoms, and nonspecific diabetes symptoms individually accounted for a significant percentage of the variance in separate exploratory predictive analytics models after controlling for demographic and clinical covariates, with small-to-large effect sizes. Conclusions: Diabetes symptoms are potentially modifiable predictors of generic HRQOL in AYA with diabetes. Identifying specific diabetes symptoms or symptoms facets that are the most important predictors from the patient perspective facilitates a patient-centered approach in clinical research, clinical trials, and practice designed to enhance overall generic HRQOL in AYA with diabetes.

KW - Diabetes

KW - Health-related quality of life

KW - Patient-reported outcomes

KW - Pediatrics

KW - PedsQL

KW - Symptoms

KW - Type 1 diabetes

KW - Type 2 diabetes

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U2 - 10.1007/s11136-018-1884-6

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