TY - JOUR
T1 - Diagnosis and management of acute myeloid leukemia in adults
T2 - Recommendations from an international expert panel, on behalf of the European LeukemiaNet
AU - Döhner, Hartmut
AU - Estey, Elihu H.
AU - Amadori, Sergio
AU - Appelbaum, Frederick R.
AU - Büchner, Thomas
AU - Burnett, Alan K.
AU - Dombret, Hervé
AU - Fenaux, Pierre
AU - Grimwade, David
AU - Larson, Richard A.
AU - Lo-Coco, Francesco
AU - Naoe, Tomoki
AU - Niederwieser, Dietger
AU - Ossenkoppele, Gert J.
AU - Sanz, Miguel A.
AU - Sierra, Jorge
AU - Tallman, Martin S.
AU - Löwenberg, Bob
AU - Bloomfield, Clara D.
PY - 2010/1/21
Y1 - 2010/1/21
N2 - In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target diseaseassociated molecular defects. Recent developments prompted an international expert panel to provide updated evidenceand expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.
AB - In 2003, an international working group last reported on recommendations for diagnosis, response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that time, considerable progress has been made in elucidating the molecular pathogenesis of the disease that has resulted in the identification of new diagnostic and prognostic markers. Furthermore, therapies are now being developed that target diseaseassociated molecular defects. Recent developments prompted an international expert panel to provide updated evidenceand expert opinion-based recommendations for the diagnosis and management of AML, that contain both minimal requirements for general practice as well as standards for clinical trials. A new standardized reporting system for correlation of cytogenetic and molecular genetic data with clinical data is proposed.
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U2 - 10.1182/blood-2009-07-235358
DO - 10.1182/blood-2009-07-235358
M3 - Review article
C2 - 19880497
AN - SCOPUS:77449159028
SN - 0006-4971
VL - 115
SP - 453
EP - 474
JO - Blood
JF - Blood
IS - 3
ER -