Diagnosis of incidental thyroid nodules on 18F-fluorodeoxyglucose positron emission tomography imaging: Are these significant?

S. D. Sharma*, T. Jacques, S. Smith, G. Watters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To determine the prevalence of thyroid malignancy in the first UK case series of patients with incidentally detected thyroid lesions on 18F-fluorodeoxyglucose positron emission tomography imaging. Methods: A total of 235 patients were evaluated with 18F-fluorodeoxyglucose positron emission tomography imaging. Incidental focal uptake in the thyroid gland was identified in nine patients (3.8 per cent). A retrospective review of their case notes was conducted. Results: The rate of malignancy was 55 per cent. The mean and standard deviation of the maximum standardised uptake value was 13.1 ± 7.3 in those patients with malignancy and a nodule identified as positive on positron emission tomography. This value was 2.8 ± 1.2 in those patients without malignancy but with a nodule identified as positive on positron emission tomography (p = 0.01). A palpable thyroid nodule was more likely in those with malignant lesions (p = 0.14). Conclusion: The prevalence of incidental thyroid lesions found on 18F-fluorodeoxyglucose positron emission tomography in patients with other primary malignancies is low, but the incidence of malignancy in these patients is high. Patients with a palpable thyroid nodule, focal uptake on 18F-fluorodeoxyglucose positron emission tomography and an increased maximum standardised uptake value require further investigation.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalJournal of Laryngology and Otology
Volume129
Issue number1
DOIs
StatePublished - Jan 10 2015
Externally publishedYes

Keywords

  • Emission-Computed Tomography
  • Thyroid Cancer
  • Thyroid Nodule

ASJC Scopus subject areas

  • Otorhinolaryngology

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