Diagnosis of phosphaturic mesenchymal tumor (mixed connective tissue type) by cytopathology

Josette William*, William Laskin, Ritu Nayar, Denise De Frias

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Oncogenic osteomalacia (OO) is a rare paraneoplastic condition in which a bone or soft tissue tumor induces biochemical and clinical signs and symptoms of osteomalacia (or rickets) most often by the production of the phosphaturic protein, fibroblast growth factor-23. Phosphaturic mesenchymal tumor, mixed connective tissue type (PMTMCT) is a rare, histologically distinct tumor that represents the most common cause of OO. As the clinical diagnosis of OO is typically suspected on the basis of clinical and biochemical features and the presence of a bone or soft tissue tumor, cytologic examination might potentially provide the necessary pathologic confirmation of OO. In this case of a 46-year-old female with clinical stigmata of OO and a right distal humeral mass, we report that the fine-needle aspiration findings of short, cytologically bland spindled cells embedded in a fine, fibrillary stromal-rich matrix and the presence of osteoclast-type giant cells associated with the stromal matrix provide strong pathological evidence for PMTMCT and assist in pathologically confirming the clinical impression of OO, thus alleviating the need for a more invasive diagnostic surgical procedure Diagn. Cytopathol. 2012.

Original languageEnglish (US)
Pages (from-to)E109-E113
JournalDiagnostic cytopathology
Issue numberSUPPL. 2
StatePublished - Aug 1 2012


  • core biopsy
  • cytology
  • fine-needle aspiration
  • oncogenic osteomalacia
  • phosphaturic mesenchymal tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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