Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

A. T. Tharapel; M. L. Moretti; C. M. Meyers; L. P. Shulman; R. E. Tipton; J. B. Summitt; S. Elias; R. S. Wilroy; M. Epps; J. L. Simpson

doi:10.1055/s-2007-999483

Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

A. T. Tharapel, M. L. Moretti, C. M. Meyers, L. P. Shulman, R. E. Tipton, J. B. Summitt, S. Elias, R. S. Wilroy, M. Epps, J. L. Simpson

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Cytogenetic methodology recently developed by us allows spontaneously dividing cells in fetal cord blood to be used for rapid (24 hours) chromosome analysis. We utilized this methodology to diagnose trisomy 18 and facilitate clinical management in a 32-week pregnancy characterized by multiple fetal anomalies and intrauterine growth retardation.

Original language	English (US)
Pages (from-to)	211-213
Number of pages	3
Journal	American journal of perinatology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1055/s-2007-999483
State	Published - Jul 1990

ASJC Scopus subject areas

Obstetrics and Gynecology
Pediatrics, Perinatology, and Child Health

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Tharapel, A. T., Moretti, M. L., Meyers, C. M., Shulman, L. P., Tipton, R. E., Summitt, J. B., Elias, S., Wilroy, R. S., Epps, M., & Simpson, J. L. (1990). Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis. American journal of perinatology, 7(3), 211-213. https://doi.org/10.1055/s-2007-999483

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abstract = "Cytogenetic methodology recently developed by us allows spontaneously dividing cells in fetal cord blood to be used for rapid (24 hours) chromosome analysis. We utilized this methodology to diagnose trisomy 18 and facilitate clinical management in a 32-week pregnancy characterized by multiple fetal anomalies and intrauterine growth retardation.",

author = "Tharapel, {A. T.} and Moretti, {M. L.} and Meyers, {C. M.} and Shulman, {L. P.} and Tipton, {R. E.} and Summitt, {J. B.} and S. Elias and Wilroy, {R. S.} and M. Epps and Simpson, {J. L.}",

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Tharapel, AT, Moretti, ML, Meyers, CM, Shulman, LP, Tipton, RE, Summitt, JB, Elias, S, Wilroy, RS, Epps, M & Simpson, JL 1990, 'Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis', American journal of perinatology, vol. 7, no. 3, pp. 211-213. https://doi.org/10.1055/s-2007-999483

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T2 - A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

AU - Tharapel, A. T.

AU - Moretti, M. L.

AU - Meyers, C. M.

AU - Shulman, L. P.

AU - Tipton, R. E.

AU - Summitt, J. B.

AU - Elias, S.

AU - Wilroy, R. S.

AU - Epps, M.

AU - Simpson, J. L.

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AB - Cytogenetic methodology recently developed by us allows spontaneously dividing cells in fetal cord blood to be used for rapid (24 hours) chromosome analysis. We utilized this methodology to diagnose trisomy 18 and facilitate clinical management in a 32-week pregnancy characterized by multiple fetal anomalies and intrauterine growth retardation.

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Diagnosis of Trisomy 18 Using Spontaneously Dividing Cells from Fetal Umbilical Cord Blood: A Novel Approach for Rapid Late Second and Third Trimester Prenatal Diagnosis

Abstract

ASJC Scopus subject areas

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