Diagnosis, risk stratification, and treatment of peripheral T-Cell lymphomas: Past and present

William B. Pearse, Barbara Pro

Research output: Contribution to journalReview articlepeer-review

Abstract

Peripheral T-cell lymphomas represent an evolving class of aggressive T-cell malignancies that are generally refractory to conventional treatments and historically carry a poor prognosis. Recent advances in gene expression profiling have begun to unravel the specific molecular mechanisms of tumorigenesis in these disease processes, allowing for discrete classification schemes that help guide discussions regarding prognosis and therapy options. We outline here a review of the histopathology, epidemiology, clinical features, and treatment strategies currently used in the management of these diseases.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalCancer Journal (United States)
Volume26
Issue number3
DOIs
StatePublished - May 1 2020

Keywords

  • Front line therapy
  • genetic profiling
  • novel agents
  • peripheral T-cell lymphoma
  • relapsed/refractory disease
  • stem cell transplantation
  • targeted therapies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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