Diagnostic delay in progressive multifocal leukoencephalopathy

Dhanashri P. Miskin, Long H. Ngo, Igor J. Koralnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We investigated delay in diagnosing progressive multifocal leukoencephalopathy (PML). The median time from initial symptom to diagnosis was 74 days (range 1-1643) in 111 PML patients seen at our institution from 1993 to 2015. Another diagnosis was considered before PML in nearly two-thirds, and more than three-quarters of patients suffered from diagnostic delay greater than 1 month, irrespective of their underlying immunosuppressive condition. Extended diagnostic delay occurred more frequently in patients with possible PML, and among HIV+ patients with higher CD4+ T-cell counts at symptom onset. Prompt diagnosis may improve survival of PML in so far as immune reconstitution can be effected, and prevent unnecessary interventions.

Original languageEnglish (US)
Pages (from-to)386-391
Number of pages6
JournalAnnals of clinical and translational neurology
Issue number5
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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