TY - JOUR
T1 - Diagnostic value of coagulation factor and intracranial pressure monitoring in acute liver failure from heat stroke
T2 - Case report and review of the literature
AU - Ramanathan, Meera
AU - Pedersen, M.
AU - Ramsey, R.
AU - Seetharam, A.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Background Exertional heat stroke (HS) with resultant acute liver failure (ALF) is a rare condition with high mortality. Diagnosis of ALF in the context of HS is confounded by numerous laboratory abnormalities related to multisystem organ dysfunction. Case Report We present the case of a 20-year-old male athlete with exertional HS who developed ALF and was treated successfully with orthotopic liver transplantation. He remained well after 1 year with normal liver function and no permanent neurologic impairment. Diagnosis and treatment was guided by serial monitoring of coagulation factors and intracranial pressure (ICP). Conclusions Currently, there are no well validated prognostic tools that predict the need for or survival with orthotopic liver transplantation for HS. We propose that serial monitoring of coagulation factors and, when safe and feasible, ICP monitoring may help to guide clinical decision making in this context.
AB - Background Exertional heat stroke (HS) with resultant acute liver failure (ALF) is a rare condition with high mortality. Diagnosis of ALF in the context of HS is confounded by numerous laboratory abnormalities related to multisystem organ dysfunction. Case Report We present the case of a 20-year-old male athlete with exertional HS who developed ALF and was treated successfully with orthotopic liver transplantation. He remained well after 1 year with normal liver function and no permanent neurologic impairment. Diagnosis and treatment was guided by serial monitoring of coagulation factors and intracranial pressure (ICP). Conclusions Currently, there are no well validated prognostic tools that predict the need for or survival with orthotopic liver transplantation for HS. We propose that serial monitoring of coagulation factors and, when safe and feasible, ICP monitoring may help to guide clinical decision making in this context.
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U2 - 10.1016/j.transproceed.2015.02.007
DO - 10.1016/j.transproceed.2015.02.007
M3 - Article
C2 - 25891738
AN - SCOPUS:84928330136
SN - 0041-1345
VL - 47
SP - 817
EP - 819
JO - Transplantation proceedings
JF - Transplantation proceedings
IS - 3
ER -