Diaphragm pacing with a quadripolar phrenic nerve electrode: An international study

Debra E. Weese-Mayer*, Jean M. Silvestri, Anna S. Kenny, Michel N. Ilbawi, Susan A. Hauptman, Jack W. Lipton, Pasi P. Talonen, Honesto Garrido Garcia, John W. Watt, Gerhard Exner, Gerhard A. Baer, John A. Elefteriades, William T. Peruzzi, Charles G. Alex, Richard Harlid, Wolter Vincken, G. Michael Davis, Marc Decramer, Christoph Kuenzle, Arne SæterhaugJohannes G. Schöber

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

We sought to determine the international experience with the quadripolar diaphragm pacer system and to test two hypotheses: the incidence of pacer complications would be (1) increased among pediatric as compared to adult patients; and (2) highest among active pediatric patients with idiopathic congenital central hypoventilation syndrome (CCHS). Data were collected via a questionnaire coupled with the Atrotech Registry data for a total of 64 patients (35 children and 29 adults)from 14 countries. Thoracic implantation of electrodes and bilateral pacer use each occurred in 94% of all subjects. Tetraplegic (vs pediatric CCHS) patients were more typically paced 24 hours/day (P = 0.001). Pacing duration averaged 2.0 ± 1.0 years among children and 2.2 ± 1.1 years among adults. Infections occurred among 2.9% of surgical procedures, all in pediatric CCHS patients (vs pediatric tetraplegic patients, P = 0.01). The incidence of mechanical trauma was 3.8%, without significant differences among patient groups. The incidence of presumed electrode and receiver failure were 3.1% and 5.9%, respectively, with internal component failure greater among pediatric CCHS than pediatric tetraplegic patients (P < 0.01). Intermittent or absent function of 0-4 electrode combinations occurred among 19% of all patients, with increased frequency among pediatric CCHS than pediatric tetraplegic patients (P < 0.03). Complication-free successful pacing occurred in 60% of pediatric and 52% of adult patients. In all, 94% of the pediatric and 86% of the adult patients paced successfully after the necessary intervention. Although pacer complications were not increased among pediatric as compared to adult patients, the incidence of complications was highest among the active pediatric patients with CCHS. Longitudinal study of these patients will provide invaluable information for modification and improvement of the quadripolar system.

Original languageEnglish (US)
Pages (from-to)1311-1319
Number of pages9
JournalPACE - Pacing and Clinical Electrophysiology
Volume19
Issue number9
DOIs
StatePublished - Jan 1 1996

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Keywords

  • adult
  • Congenital Central Hypoventilation syndrome
  • pediatric
  • tetraplegia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Weese-Mayer, D. E., Silvestri, J. M., Kenny, A. S., Ilbawi, M. N., Hauptman, S. A., Lipton, J. W., Talonen, P. P., Garcia, H. G., Watt, J. W., Exner, G., Baer, G. A., Elefteriades, J. A., Peruzzi, W. T., Alex, C. G., Harlid, R., Vincken, W., Davis, G. M., Decramer, M., Kuenzle, C., ... Schöber, J. G. (1996). Diaphragm pacing with a quadripolar phrenic nerve electrode: An international study. PACE - Pacing and Clinical Electrophysiology, 19(9), 1311-1319. https://doi.org/10.1111/j.1540-8159.1996.tb04209.x