TY - JOUR
T1 - Diastolic filling abnormalities by color kinesis in newborns exposed to intrauterine cocaine
AU - Mehta, Sudhir Ken
AU - Super, Dennis M.
AU - Salvator, Ann
AU - Singer, Lynn
AU - Connuck, David
AU - Fradley, Linda Goetz
AU - Harcar-Sevcik, Rose A.
AU - Thomas, James D.
AU - Sun, Jing Ping
N1 - Funding Information:
Supported by NIDA (NIH) ROI-DA09049 (S.K.M.).
Funding Information:
We are thankful to the wonderful staff of General Clinical Research Center (Grant from NIH MO1RR00080 awarded to Case Western Reserve University) for their constant support and help in providing great care to our patients and their families. We are also grateful to Dr Victor Mor-Avi for his helpful comments and for his help in the analysis of color kinesis. Thanks to Dr H. Lester Kirchner for his helpful comments regarding statistical analyses. The study would not have been possible without the dedication and expertise of Maureen Babjak, Linda Wiersma, Cindy Holliday, and Allen Borowski.
PY - 2002/5
Y1 - 2002/5
N2 - Because cocaine crosses the placenta, we prospectively evaluated global and segmental systolic and diastolic cardiac function by color kinesis in clinically asymptomatic newborns who were exposed to cocaine in utero (group 1, n = 82). Their data were compared with normal controls (group 3, n = 87) and newborns exposed to drugs other than cocaine (group 2, n = 108). During left ventricular filling, newborns exposed to cocaine, compared with groups 2 and 3, had significantly (P < .05) higher global fractional area change (%) (76 ± 10.3 vs 72 ± 9.4 and 72 ± 9.1, respectively), regional fractional area changes (%) for the anterior, septal, inferior, and lateral wall, and in the index of asynchrony (at 50% filling 13.2 ± 5.8 vs 11.3 ± 4.1 and 11.6 ± 4.2, respectively). There were no significant differences in systolic function among the 3 groups. Prenatal cocaine exposure in asymptomatic infants leads to higher global and segmental fractional area changes and asynchrony during diastole. The significance and course of these alterations require further investigation.
AB - Because cocaine crosses the placenta, we prospectively evaluated global and segmental systolic and diastolic cardiac function by color kinesis in clinically asymptomatic newborns who were exposed to cocaine in utero (group 1, n = 82). Their data were compared with normal controls (group 3, n = 87) and newborns exposed to drugs other than cocaine (group 2, n = 108). During left ventricular filling, newborns exposed to cocaine, compared with groups 2 and 3, had significantly (P < .05) higher global fractional area change (%) (76 ± 10.3 vs 72 ± 9.4 and 72 ± 9.1, respectively), regional fractional area changes (%) for the anterior, septal, inferior, and lateral wall, and in the index of asynchrony (at 50% filling 13.2 ± 5.8 vs 11.3 ± 4.1 and 11.6 ± 4.2, respectively). There were no significant differences in systolic function among the 3 groups. Prenatal cocaine exposure in asymptomatic infants leads to higher global and segmental fractional area changes and asynchrony during diastole. The significance and course of these alterations require further investigation.
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U2 - 10.1067/mje.2002.117296
DO - 10.1067/mje.2002.117296
M3 - Article
C2 - 12019428
AN - SCOPUS:0036583029
SN - 0894-7317
VL - 15
SP - 447
EP - 453
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 5
ER -