Diastolic filling abnormalities by color kinesis in newborns exposed to intrauterine cocaine

Sudhir Ken Mehta*, Dennis M. Super, Ann Salvator, Lynn Singer, David Connuck, Linda Goetz Fradley, Rose A. Harcar-Sevcik, James D. Thomas, Jing Ping Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Because cocaine crosses the placenta, we prospectively evaluated global and segmental systolic and diastolic cardiac function by color kinesis in clinically asymptomatic newborns who were exposed to cocaine in utero (group 1, n = 82). Their data were compared with normal controls (group 3, n = 87) and newborns exposed to drugs other than cocaine (group 2, n = 108). During left ventricular filling, newborns exposed to cocaine, compared with groups 2 and 3, had significantly (P < .05) higher global fractional area change (%) (76 ± 10.3 vs 72 ± 9.4 and 72 ± 9.1, respectively), regional fractional area changes (%) for the anterior, septal, inferior, and lateral wall, and in the index of asynchrony (at 50% filling 13.2 ± 5.8 vs 11.3 ± 4.1 and 11.6 ± 4.2, respectively). There were no significant differences in systolic function among the 3 groups. Prenatal cocaine exposure in asymptomatic infants leads to higher global and segmental fractional area changes and asynchrony during diastole. The significance and course of these alterations require further investigation.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalJournal of the American Society of Echocardiography
Issue number5
StatePublished - May 2002

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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