Diastolic function using 3-D echo reconstruction and finite element analysis: applications for study in animal models and patients

We have initiated animal experiments using three-dimensional reconstruction of echocardiographic recordings and finite element analysis to evaluate the effects of alterations in preload, afterload and contractility on diastolic function. With the use of implantable echogenic teflon beads, we are also evaluating the effects of cardiac translation and rotation on the three-dimensional reconstruction and finite element analysis model. Whilst evaluating these changes, we have collected data on eleven normal subjects and will be using three-dimensional reconstruction and finite element analysis to predict the normal range of diastolic elastic myocardial properties. With the identification of these parameters (preload, afterload, contractility, translation and rotation, and normal human elastic properties), we can proceed to evaluate alterations in passive myocardial elastic properties in patients with acute ischemia, infarction, and chronic infarction with fibrosis. The ultimate goal of these studies is to develop a clinically useful model that will allow evaluation of regional ventricular function and changes in regional ventricular function due to pathologic states.