TY - JOUR
T1 - Diet-induced changes in sympathetic nervous system activity
T2 - Possible implications for obesity and hypertension
AU - Young, James B.
AU - Landsberg, Lewis
N1 - Funding Information:
Supported by USPHS Grants AM 20378, AM 26455 and HL 24084. Published, by special editorial arrangement, as part of the Proceedings of a Symposium on Obesity and Hypertension held by the International Society on Hypertension in Jackson, Mississippi May 1980.
PY - 1982
Y1 - 1982
N2 - The sympathetic nervous system responds to changes in caloric intake; caloric restriction decreases and carbohydrate administration increases sympathetic nervous system activity in animals and man. Insulin may be a major link between changes in dietary intake and changes in central sympathetic outflow. Caloric restriction reduces, and carbohydrate administration increases blood pressure in spontaneously hypertensive rats, changes consistent with a primary effect of caloric intake on sympathetic nervous system activity. Stimulation of the sympathetic nervous system by overfeeding may contribute to the development and maintenance of hypertension in biologically-predisposed animals and man. The association of obesity and hypertension may reflect chronic overfeeding, although diet-induced changes in sympathetic nervous system activity may affect blood pressure in non-obese individuals as well.
AB - The sympathetic nervous system responds to changes in caloric intake; caloric restriction decreases and carbohydrate administration increases sympathetic nervous system activity in animals and man. Insulin may be a major link between changes in dietary intake and changes in central sympathetic outflow. Caloric restriction reduces, and carbohydrate administration increases blood pressure in spontaneously hypertensive rats, changes consistent with a primary effect of caloric intake on sympathetic nervous system activity. Stimulation of the sympathetic nervous system by overfeeding may contribute to the development and maintenance of hypertension in biologically-predisposed animals and man. The association of obesity and hypertension may reflect chronic overfeeding, although diet-induced changes in sympathetic nervous system activity may affect blood pressure in non-obese individuals as well.
UR - http://www.scopus.com/inward/record.url?scp=0020373986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020373986&partnerID=8YFLogxK
U2 - 10.1016/0021-9681(82)90118-7
DO - 10.1016/0021-9681(82)90118-7
M3 - Article
C2 - 6816809
AN - SCOPUS:0020373986
SN - 0895-4356
VL - 35
SP - 879
EP - 886
JO - American journal of syphilis, gonorrhea, and venereal diseases
JF - American journal of syphilis, gonorrhea, and venereal diseases
IS - 12
ER -
