Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry

Dominique Kosk; Holly Kramer; Amy Luke; Pauline Camacho; Pascal Bovet; Jacob Plange Rhule; Terrence Forrester; Myles Wolf; Chris Sempos; Michal L. Melamed; Lara R. Dugas; Richard Cooper; Ramon Durazo-Arvizu

doi:10.1007/s00774-016-0804-5

Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry

Dominique Kosk, Holly Kramer^*, Amy Luke, Pauline Camacho, Pascal Bovet, Jacob Plange Rhule, Terrence Forrester, Myles Wolf, Chris Sempos, Michal L. Melamed, Lara R. Dugas, Richard Cooper, Ramon Durazo-Arvizu

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m² to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P < 0.001). Dietary factors other than phosphate are associated with FGF23 levels in young adults.

Original language	English (US)
Pages (from-to)	666-674
Number of pages	9
Journal	Journal of Bone and Mineral Metabolism
Volume	35
Issue number	6
DOIs	https://doi.org/10.1007/s00774-016-0804-5
State	Published - Nov 1 2017

Funding

American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago–Intramural Award LU#204006. Data were presented in poster form at the American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago?Intramural Award LU#204006. The authors have no conflicts of interest to disclose.

Keywords

Calcium intake
FGF23
Fibroblast growth factor 23
Phosphate intake
Vitamin D

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine

Access to Document

10.1007/s00774-016-0804-5

Cite this

@article{00c99f9b45d2405eaafbb5296cfd69e7,

title = "Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry",

abstract = "Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3\% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P < 0.001). Dietary factors other than phosphate are associated with FGF23 levels in young adults.",

keywords = "Calcium intake, FGF23, Fibroblast growth factor 23, Phosphate intake, Vitamin D",

author = "Dominique Kosk and Holly Kramer and Amy Luke and Pauline Camacho and Pascal Bovet and Rhule, \{Jacob Plange\} and Terrence Forrester and Myles Wolf and Chris Sempos and Melamed, \{Michal L.\} and Dugas, \{Lara R.\} and Richard Cooper and Ramon Durazo-Arvizu",

note = "Funding Information: American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago–Intramural Award LU\#204006. Funding Information: Data were presented in poster form at the American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago?Intramural Award LU\#204006. The authors have no conflicts of interest to disclose. Publisher Copyright: {\textcopyright} 2016, The Japanese Society for Bone and Mineral Research and Springer Japan.",

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doi = "10.1007/s00774-016-0804-5",

language = "English (US)",

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T1 - Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry

AU - Kosk, Dominique

AU - Kramer, Holly

AU - Luke, Amy

AU - Camacho, Pauline

AU - Bovet, Pascal

AU - Rhule, Jacob Plange

AU - Forrester, Terrence

AU - Wolf, Myles

AU - Sempos, Chris

AU - Melamed, Michal L.

AU - Dugas, Lara R.

AU - Cooper, Richard

AU - Durazo-Arvizu, Ramon

N1 - Funding Information: American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago–Intramural Award LU#204006. Funding Information: Data were presented in poster form at the American Public Health Association Meeting October 2015, Chicago IL (DK). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health or the US Department of Health and Human Services. This study was supported in part by funding from the National Institutes of Health 1R01DK90360-1A1 (RD), 5R01DK080763-04 (AL), and by Loyola University Chicago?Intramural Award LU#204006. The authors have no conflicts of interest to disclose. Publisher Copyright: © 2016, The Japanese Society for Bone and Mineral Research and Springer Japan.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P < 0.001). Dietary factors other than phosphate are associated with FGF23 levels in young adults.

AB - Fibroblast growth factor-23 (FGF23), a phosphaturic hormone secreted mainly by osteocytes, maintains serum phosphate levels within a tight range by promoting phosphaturia. Previous studies have mainly focused on the link between FGF23 levels and dietary intake of phosphate, but other dietary factors may also influence FGF23 levels. This cross-sectional study pooled three populations of young adults with African ancestry (452 in Chicago, IL, USA; 477 in Victoria, Seychelles; and 482 in Kumasi, Ghana) with estimated glomerular filtration rate >80 ml/min/1.73 m2 to examine the association of dietary factors based on two 24-h recalls with FGF23 levels measured using a C-terminal assay. Linear regression was used to examine the association between log-transformed FGF23 levels and quartiles of calorie-adjusted dietary factors with adjustment for covariates. In the pooled sample of 1411 study participants, the mean age was 35.2 (6.2) years and 45.3% were male. Median plasma C-terminal FGF23 values in relative units (RU)/ml were 59.5 [interquartile range (IQR) 44.1, 85.3] in the USA, 43.2 (IQR 33.1, 57.9) in Seychelles, and 34.0 (IQR 25.2, 50.4) in Ghana. With adjustment for covariates, increasing quartiles of calcium and animal protein and decreasing quartiles of vegetable protein, fiber, and magnesium intake were associated with significantly higher FGF23 levels compared to the lowest quartile. After further adjustment for dietary factors, significant trends in FGF23 levels were noted only for quartiles of calcium, fiber, and magnesium intake (P < 0.001). Dietary factors other than phosphate are associated with FGF23 levels in young adults.

KW - Calcium intake

KW - FGF23

KW - Fibroblast growth factor 23

KW - Phosphate intake

KW - Vitamin D

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JF - Journal of Bone and Mineral Metabolism

IS - 6

ER -

Dietary factors and fibroblast growth factor-23 levels in young adults with African ancestry

Abstract

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