Dietary factors related to higher plasma fibrinogen levels of Japanese-Americans in Hawaii compared with Japanese in Japan

Katsuyuki Miura*, Hideaki Nakagawa, Hirotsugu Ueshima, Akira Okayama, Shigeyuki Saitoh, J. David Curb, Beatriz L. Rodriguez, Kiyomi Sakata, Nagako Okuda, Katsushi Yoshita, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

OBJECTIVE - We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan. METHODS AND RESULTS - Plasma fibrinogen and nutrient intakes were examined by standardized methods in men and women 40 to 59 years of age from a Japanese-American sample in Hawaii (100 men and 106 women) and 4 population samples in Japan (569 men and 567 women). Multiple linear regression models were used to examine the relationship between dietary factors and the plasma fibrinogen difference between Hawaii and Japan. Average plasma fibrinogen was significantly higher in Hawaii compared with Japan (P<0.001 in both genders). In multiple linear regression analyses with each dietary variable considered separately, body mass index reduced the plasma fibrinogen difference between Hawaii and Japan by 20.4%; iron intake (mg/1000 kcal) and estimated total sugar intake (%kcal) reduced this difference by 30.0% and 14.4%, respectively. In a model that included body mass index, iron, estimated total sugars, and caffeine (also age and gender), this difference was reduced by 61.3% (from 42.2 to 16.3 mg/dL). CONCLUSIONS - Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle.

Original languageEnglish (US)
Pages (from-to)1674-1679
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume26
Issue number7
DOIs
StatePublished - Jul 2006

Keywords

  • Caffeine
  • Fibrinogen
  • Iron
  • Nutrition
  • Obesity
  • Population study
  • Sugar

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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