Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival

CALGB 89803 (Alliance)

Erin L. Van Blarigan*, Fang Shu Ou, Donna Niedzwiecki, Sui Zhang, Charles S. Fuchs, Leonard Saltz, Robert J. Mayer, Alan Venook, Shuji Ogino, Mingyang Song, Al B Benson III, Alexander Hantel, James N. Atkins, Edward L. Giovannucci, Jeffrey A. Meyerhardt

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.

Original languageEnglish (US)
Pages (from-to)1227-1230
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2018

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Dietary Fats
Colonic Neoplasms
Recurrence
Survival
Vegetables
Fats
Neoplasms
Disease-Free Survival
Unsaturated Fats
Nuts
Adjuvant Chemotherapy
Unsaturated Fatty Acids
Cause of Death

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Van Blarigan, E. L., Ou, F. S., Niedzwiecki, D., Zhang, S., Fuchs, C. S., Saltz, L., ... Meyerhardt, J. A. (2018). Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance). Cancer Epidemiology Biomarkers and Prevention, 27(10), 1227-1230. https://doi.org/10.1158/1055-9965.EPI-18-0487
Van Blarigan, Erin L. ; Ou, Fang Shu ; Niedzwiecki, Donna ; Zhang, Sui ; Fuchs, Charles S. ; Saltz, Leonard ; Mayer, Robert J. ; Venook, Alan ; Ogino, Shuji ; Song, Mingyang ; Benson III, Al B ; Hantel, Alexander ; Atkins, James N. ; Giovannucci, Edward L. ; Meyerhardt, Jeffrey A. / Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival : CALGB 89803 (Alliance). In: Cancer Epidemiology Biomarkers and Prevention. 2018 ; Vol. 27, No. 10. pp. 1227-1230.
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title = "Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)",
abstract = "Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.",
author = "{Van Blarigan}, {Erin L.} and Ou, {Fang Shu} and Donna Niedzwiecki and Sui Zhang and Fuchs, {Charles S.} and Leonard Saltz and Mayer, {Robert J.} and Alan Venook and Shuji Ogino and Mingyang Song and {Benson III}, {Al B} and Alexander Hantel and Atkins, {James N.} and Giovannucci, {Edward L.} and Meyerhardt, {Jeffrey A.}",
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Van Blarigan, EL, Ou, FS, Niedzwiecki, D, Zhang, S, Fuchs, CS, Saltz, L, Mayer, RJ, Venook, A, Ogino, S, Song, M, Benson III, AB, Hantel, A, Atkins, JN, Giovannucci, EL & Meyerhardt, JA 2018, 'Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)', Cancer Epidemiology Biomarkers and Prevention, vol. 27, no. 10, pp. 1227-1230. https://doi.org/10.1158/1055-9965.EPI-18-0487

Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival : CALGB 89803 (Alliance). / Van Blarigan, Erin L.; Ou, Fang Shu; Niedzwiecki, Donna; Zhang, Sui; Fuchs, Charles S.; Saltz, Leonard; Mayer, Robert J.; Venook, Alan; Ogino, Shuji; Song, Mingyang; Benson III, Al B; Hantel, Alexander; Atkins, James N.; Giovannucci, Edward L.; Meyerhardt, Jeffrey A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 27, No. 10, 01.10.2018, p. 1227-1230.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival

T2 - CALGB 89803 (Alliance)

AU - Van Blarigan, Erin L.

AU - Ou, Fang Shu

AU - Niedzwiecki, Donna

AU - Zhang, Sui

AU - Fuchs, Charles S.

AU - Saltz, Leonard

AU - Mayer, Robert J.

AU - Venook, Alan

AU - Ogino, Shuji

AU - Song, Mingyang

AU - Benson III, Al B

AU - Hantel, Alexander

AU - Atkins, James N.

AU - Giovannucci, Edward L.

AU - Meyerhardt, Jeffrey A.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.

AB - Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.

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DO - 10.1158/1055-9965.EPI-18-0487

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JO - Cancer Epidemiology Biomarkers and Prevention

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SN - 1055-9965

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