Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)

Erin L. Van Blarigan; Fang Shu Ou; Donna Niedzwiecki; Sui Zhang; Charles S. Fuchs; Leonard Saltz; Robert J. Mayer; Alan Venook; Shuji Ogino; Mingyang Song; Al Benson; Alexander Hantel; James N. Atkins; Edward L. Giovannucci; Jeffrey A. Meyerhardt

doi:10.1158/1055-9965.EPI-18-0487

Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)

Erin L. Van Blarigan^*, Fang Shu Ou, Donna Niedzwiecki, Sui Zhang, Charles S. Fuchs, Leonard Saltz, Robert J. Mayer, Alan Venook, Shuji Ogino, Mingyang Song, Al Benson, Alexander Hantel, James N. Atkins, Edward L. Giovannucci, Jeffrey A. Meyerhardt

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.

Original language	English (US)
Pages (from-to)	1227-1230
Number of pages	4
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	27
Issue number	10
DOIs	https://doi.org/10.1158/1055-9965.EPI-18-0487
State	Published - Oct 2018

Funding

Research reported in this publication was supported by the NCI of NIH under award numbers U10CA180821 and U10CA180882 (to the Alliance for Clinical Trials in Oncology; D. Niedzwiecki and F. Ou), U10CA138561 (to A.P. Venook), U10CA180791 (to L. Saltz), U10CA180820 (to A. Benson), U10CA180867 (to J.A. Meyerhardt, S. Zhang, R. Mayer, and S. Ogino), U10CA180888 (to A. Hantel), UG1CA189858 (to J.N. Atkins), K07CA197077 (to E.L. Van Blarigan), R01CA118553 (to C.S. Fuchs and D. Niedzwiecki), R01CA149222 (to J.A. Meyerhardt and D. Niedzwiecki), P50CA127003 (to C.S. Fuchs and J.A. Meyerhardt), R35CA197735 (to S. Ogino), and K99CA215314 (to M. Song). Dr. Song also received support from the American Cancer Society (MRSG-17-220-01-NEC) and American Association for Cancer Research (17-40-12-SONG), and this research was supported in part by funds from Pharmacia & Upjohn Company (now Pfizer Oncology; to C. Fuchs). Finally, this research was supported in part by a Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (to C.S. Fuchs, grant number: SU2C-AACR-DT22-17). Research grants are administered by the American Association for Cancer Research, the Scientific Partner of SU2C.

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General Medicine

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10.1158/1055-9965.EPI-18-0487

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Van Blarigan, E. L., Ou, F. S., Niedzwiecki, D., Zhang, S., Fuchs, C. S., Saltz, L., Mayer, R. J., Venook, A., Ogino, S., Song, M., Benson, A., Hantel, A., Atkins, J. N., Giovannucci, E. L., & Meyerhardt, J. A. (2018). Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance). Cancer Epidemiology Biomarkers and Prevention, 27(10), 1227-1230. https://doi.org/10.1158/1055-9965.EPI-18-0487

@article{dd31e121ffcd44e1b0f244ce2e7fad78,

title = "Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)",

abstract = "Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.",

author = "{Van Blarigan}, {Erin L.} and Ou, {Fang Shu} and Donna Niedzwiecki and Sui Zhang and Fuchs, {Charles S.} and Leonard Saltz and Mayer, {Robert J.} and Alan Venook and Shuji Ogino and Mingyang Song and Al Benson and Alexander Hantel and Atkins, {James N.} and Giovannucci, {Edward L.} and Meyerhardt, {Jeffrey A.}",

note = "Publisher Copyright: {\textcopyright} 2018 American Association for Cancer Research.",

year = "2018",

month = oct,

doi = "10.1158/1055-9965.EPI-18-0487",

language = "English (US)",

volume = "27",

pages = "1227--1230",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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Van Blarigan, EL, Ou, FS, Niedzwiecki, D, Zhang, S, Fuchs, CS, Saltz, L, Mayer, RJ, Venook, A, Ogino, S, Song, M, Benson, A, Hantel, A, Atkins, JN, Giovannucci, EL & Meyerhardt, JA 2018, 'Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)', Cancer Epidemiology Biomarkers and Prevention, vol. 27, no. 10, pp. 1227-1230. https://doi.org/10.1158/1055-9965.EPI-18-0487

TY - JOUR

T1 - Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival

T2 - CALGB 89803 (Alliance)

AU - Van Blarigan, Erin L.

AU - Ou, Fang Shu

AU - Niedzwiecki, Donna

AU - Zhang, Sui

AU - Fuchs, Charles S.

AU - Saltz, Leonard

AU - Mayer, Robert J.

AU - Venook, Alan

AU - Ogino, Shuji

AU - Song, Mingyang

AU - Benson, Al

AU - Hantel, Alexander

AU - Atkins, James N.

AU - Giovannucci, Edward L.

AU - Meyerhardt, Jeffrey A.

PY - 2018/10

Y1 - 2018/10

N2 - Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.

AB - Background: Higher intake of long-chain ω-3 polyunsaturated fatty acids and nuts, rich plant sources of unsaturated fats, after colon cancer diagnosis are associated with improved survival. It isnot known whether theamount or the distribution of other types of fat is associated with survival after coloncancer. Methods: We prospectively examined postdiagnostic total, animal, and vegetable fats, as well as the saturated, monounsaturated, polyunsaturated, and trans fat in relation to disease-free survival among 1,011 patients with stage III colon cancer. Patients were enrolled between 1999 and 2001 at the onset of adjuvant chemotherapy and followed for recurrence or death through 2009. Results: During median follow-up of 7 years, we observed 305 deaths and 81 recurrences (total events: 386). Neither total nor any specific type of dietary fat examined was statistically significantly associated with risk of cancer recurrence or death from any cause (disease-free survival) after stage III colon cancer. Conclusions: The amount and type (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer does not appear to be substantially associated with risk of recurrence or survival. Impact: Neither total nor major types (animal, vegetable, saturated, monounsaturated, polyunsaturated, and trans) of dietary fat consumed after colon cancer was associated with cancer recurrence or survival.

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JO - Cancer Epidemiology Biomarkers and Prevention

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ER -

Dietary fat intake after colon cancer diagnosis in relation to cancer recurrence and survival: CALGB 89803 (Alliance)

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UN SDGs

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