Abstract
Experimental and clinical trial data have suggested an association between fish oil intake and atrial fibrillation (AF). However, previous observational studies have reported conflicting results regarding this association. Thus, we sought to compare the association between dietary fish intake and incident AF in a large sample of older, postmenopausal women. We included 44,720 participants from the Women's Health Initiative clinical trials who were not enrolled in the dietary modification intervention arm and without AF at baseline. The dietary intake of nonfried fish and omega-3 fatty acid intake was estimated from a Food Frequency Questionnaire at study entry. Incident AF was determined by follow-up electrocardiography at years 3 and 6. The baseline characteristics and rates of incident AF were compared across the quartiles of fish intake. Adjusted logistic regression models were used to evaluate the association between dietary nonfried fish intake and incident AF. A total of 378 incident cases of AF occurred during the follow-up period. In the age-adjusted models, no association was found between dietary nonfried fish intake and incident AF (odds ratio 1.17, 95% confidence interval 0.88 to 1.57 for quartile 4 vs quartile 1 of dietary fish intake). Similar findings were observed in the multivariate models and in the subgroup analyses. In conclusion, in a large cohort of healthy women, we found no evidence of an association between fish or omega-3 fatty acid intake and incident AF.
Original language | English (US) |
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Pages (from-to) | 844-848 |
Number of pages | 5 |
Journal | American Journal of Cardiology |
Volume | 105 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2010 |
Funding
The Women's Health Initiative program was funded by the National Heart, and Lung, and Blood Institute of the National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Dr. Berry is currently funded by grant K23 HL092229 from the National Heart, Lung, and Blood Institute , Bethesda, Maryland, and by the Dedman Family Scholar in Clinical Care endowment at University of Texas Southwestern. Dr. Lloyd-Jones is supported in part by grants R21HL085375 and R01HL086792-02 from the National Heart, Lung, and Blood Institute , Bethesda, Maryland.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine