Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence

A Pooled Analysis

C. L. Sardo Molmenti*, S. E. Steck, C. A. Thomson, Elizabeth A Hibler, J. Yang, N. Shivappa, H. Greenlee, M. D. Wirth, A. I. Neugut, E. T. Jacobs, J. R. Hébert

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

No studies have evaluated the association between the dietary inflammatory index (DII) and colorectal adenoma recurrence. DII scores were calculated from a baseline food frequency questionnaire. Participants (n = 1727) were 40–80 years of age, enrolled in two Phase III clinical trials, who had ≥1 colorectal adenoma(s) removed within 6 months of study registration, and a follow-up colonoscopy during the trial. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). No statistically significant associations were found between DII and odds of colorectal adenoma recurrence [ORs (95% CIs) = 0.93 (0.73, 1.18) and 0.95 (0.73, 1.22)] for subjects in the second and third DII tertiles, respectively, compared to those in the lowest tertile (Ptrend = 0.72). No associations were found for recurrent colorectal adenoma characteristics, including advanced recurrent adenomas, large size, villous histology, or anatomic location. While our study did not support an association between a proinflammatory diet and colorectal adenoma recurrence, future studies are warranted to elucidate the role of a proinflammatory diet on the early stages of colorectal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)238-247
Number of pages10
JournalNutrition and Cancer
Volume69
Issue number2
DOIs
StatePublished - Feb 17 2017

Fingerprint

Adenoma
Recurrence
Odds Ratio
Confidence Intervals
Diet
Phase III Clinical Trials
Colonoscopy
Histology
Carcinogenesis
Logistic Models
Food

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Sardo Molmenti, C. L., Steck, S. E., Thomson, C. A., Hibler, E. A., Yang, J., Shivappa, N., ... Hébert, J. R. (2017). Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence: A Pooled Analysis. Nutrition and Cancer, 69(2), 238-247. https://doi.org/10.1080/01635581.2017.1263752
Sardo Molmenti, C. L. ; Steck, S. E. ; Thomson, C. A. ; Hibler, Elizabeth A ; Yang, J. ; Shivappa, N. ; Greenlee, H. ; Wirth, M. D. ; Neugut, A. I. ; Jacobs, E. T. ; Hébert, J. R. / Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence : A Pooled Analysis. In: Nutrition and Cancer. 2017 ; Vol. 69, No. 2. pp. 238-247.
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Sardo Molmenti, CL, Steck, SE, Thomson, CA, Hibler, EA, Yang, J, Shivappa, N, Greenlee, H, Wirth, MD, Neugut, AI, Jacobs, ET & Hébert, JR 2017, 'Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence: A Pooled Analysis', Nutrition and Cancer, vol. 69, no. 2, pp. 238-247. https://doi.org/10.1080/01635581.2017.1263752

Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence : A Pooled Analysis. / Sardo Molmenti, C. L.; Steck, S. E.; Thomson, C. A.; Hibler, Elizabeth A; Yang, J.; Shivappa, N.; Greenlee, H.; Wirth, M. D.; Neugut, A. I.; Jacobs, E. T.; Hébert, J. R.

In: Nutrition and Cancer, Vol. 69, No. 2, 17.02.2017, p. 238-247.

Research output: Contribution to journalArticle

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T1 - Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence

T2 - A Pooled Analysis

AU - Sardo Molmenti, C. L.

AU - Steck, S. E.

AU - Thomson, C. A.

AU - Hibler, Elizabeth A

AU - Yang, J.

AU - Shivappa, N.

AU - Greenlee, H.

AU - Wirth, M. D.

AU - Neugut, A. I.

AU - Jacobs, E. T.

AU - Hébert, J. R.

PY - 2017/2/17

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N2 - No studies have evaluated the association between the dietary inflammatory index (DII) and colorectal adenoma recurrence. DII scores were calculated from a baseline food frequency questionnaire. Participants (n = 1727) were 40–80 years of age, enrolled in two Phase III clinical trials, who had ≥1 colorectal adenoma(s) removed within 6 months of study registration, and a follow-up colonoscopy during the trial. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). No statistically significant associations were found between DII and odds of colorectal adenoma recurrence [ORs (95% CIs) = 0.93 (0.73, 1.18) and 0.95 (0.73, 1.22)] for subjects in the second and third DII tertiles, respectively, compared to those in the lowest tertile (Ptrend = 0.72). No associations were found for recurrent colorectal adenoma characteristics, including advanced recurrent adenomas, large size, villous histology, or anatomic location. While our study did not support an association between a proinflammatory diet and colorectal adenoma recurrence, future studies are warranted to elucidate the role of a proinflammatory diet on the early stages of colorectal carcinogenesis.

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