Dietary Inflammatory Index and Risk of Colorectal Adenoma Recurrence: A Pooled Analysis

C. L. Sardo Molmenti*, S. E. Steck, C. A. Thomson, E. A. Hibler, J. Yang, N. Shivappa, H. Greenlee, M. D. Wirth, A. I. Neugut, E. T. Jacobs, J. R. Hébert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


No studies have evaluated the association between the dietary inflammatory index (DII) and colorectal adenoma recurrence. DII scores were calculated from a baseline food frequency questionnaire. Participants (n = 1727) were 40–80 years of age, enrolled in two Phase III clinical trials, who had ≥1 colorectal adenoma(s) removed within 6 months of study registration, and a follow-up colonoscopy during the trial. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). No statistically significant associations were found between DII and odds of colorectal adenoma recurrence [ORs (95% CIs) = 0.93 (0.73, 1.18) and 0.95 (0.73, 1.22)] for subjects in the second and third DII tertiles, respectively, compared to those in the lowest tertile (Ptrend = 0.72). No associations were found for recurrent colorectal adenoma characteristics, including advanced recurrent adenomas, large size, villous histology, or anatomic location. While our study did not support an association between a proinflammatory diet and colorectal adenoma recurrence, future studies are warranted to elucidate the role of a proinflammatory diet on the early stages of colorectal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)238-247
Number of pages10
JournalNutrition and Cancer
Issue number2
StatePublished - Feb 17 2017

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research


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