TY - JOUR
T1 - Dietary intake of fiber, fruit and vegetables decreases the risk of incident kidney stones in women
T2 - A women's health initiative report
AU - Sorensen, Mathew D.
AU - Hsi, Ryan S.
AU - Chi, Thomas
AU - Shara, Nawar
AU - Wactawski-Wende, Jean
AU - Kahn, Arnold J.
AU - Wang, Hong
AU - Hou, Lifang
AU - Stoller, Marshall L.
N1 - Funding Information:
Supported by the National Center for Advancing Translational Sciences , National Institutes of Health UL1TR000101 (previously UL1RR031975), through the Clinical and Translational Science Awards Program, a trademark of DHHS, part of the Roadmap Initiative, “Re-Engineering the Clinical Research Enterprise.”
Funding Information:
The Women’s Health Initiative (WHI) program is funded by the National Heart, Lung, and Blood Institute , National Institutes of Health , U.S. Department of Health and Human Services (DHHS) , through contracts HHSN268201100046C , HHSN268201100001C , HHSN268201100002C , HHSN268201100003C , HHSN268201100004C and HHSN271201100004C , and these funding sources had initial input on WHI study design. For this particular study the funding source had no role in the study design, analyses, interpretation, reporting or publication of these data. The WHI publications committee approved the final version of this manuscript. This material is also the result of work supported by resources from the VA Puget Sound Health Care System, Seattle, Washington.
Publisher Copyright:
© 2014 American Urological Association Education and Research, Inc.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Results Mean age of the women was 64±7 years, 85% were white and 2,937 (3.5%) experienced a kidney stone in a median followup of 8 years. In women with no history of kidney stones higher total dietary fiber (6% to 26% decreased risk, p <0.001), greater fruit intake (12% to 25% decreased risk, p <0.001) and greater vegetable intake (9% to 22% decreased risk, p=0.002) were associated with a decreased risk of incident kidney stone formation in separate adjusted models. In women with a history of stones there were no significant protective effects of fiber, fruit or vegetable intake on the risk of kidney stone recurrence.Conclusions Greater dietary intake of fiber, fruits and vegetables was associated with a reduced risk of incident kidney stones in postmenopausal women. The protective effects were independent of other known risk factors for kidney stones. In contrast, there was no reduction in risk in women with a history of stones.Materials and Methods Overall 83,922 postmenopausal women from the Women's Health Initiative observational study were included in the analysis and followed prospectively. Cox proportional hazards regression analyses were used to evaluate the associations between total dietary fiber, fruit and vegetable intake, and the risk of incident kidney stone formation, adjusting for nephrolithiasis risk factors (age, race/ethnicity, geographic region, diabetes mellitus, calcium supplementation, hormone therapy use, body mass index and calibrated caloric intake; and dietary water, sodium, animal protein and calcium intake). Women with a history of kidney stones (3,471) were analyzed separately.Purpose We evaluated the relationship between dietary fiber, fruit and vegetable intake, and the risk of kidney stone formation.
AB - Results Mean age of the women was 64±7 years, 85% were white and 2,937 (3.5%) experienced a kidney stone in a median followup of 8 years. In women with no history of kidney stones higher total dietary fiber (6% to 26% decreased risk, p <0.001), greater fruit intake (12% to 25% decreased risk, p <0.001) and greater vegetable intake (9% to 22% decreased risk, p=0.002) were associated with a decreased risk of incident kidney stone formation in separate adjusted models. In women with a history of stones there were no significant protective effects of fiber, fruit or vegetable intake on the risk of kidney stone recurrence.Conclusions Greater dietary intake of fiber, fruits and vegetables was associated with a reduced risk of incident kidney stones in postmenopausal women. The protective effects were independent of other known risk factors for kidney stones. In contrast, there was no reduction in risk in women with a history of stones.Materials and Methods Overall 83,922 postmenopausal women from the Women's Health Initiative observational study were included in the analysis and followed prospectively. Cox proportional hazards regression analyses were used to evaluate the associations between total dietary fiber, fruit and vegetable intake, and the risk of incident kidney stone formation, adjusting for nephrolithiasis risk factors (age, race/ethnicity, geographic region, diabetes mellitus, calcium supplementation, hormone therapy use, body mass index and calibrated caloric intake; and dietary water, sodium, animal protein and calcium intake). Women with a history of kidney stones (3,471) were analyzed separately.Purpose We evaluated the relationship between dietary fiber, fruit and vegetable intake, and the risk of kidney stone formation.
KW - dietary fiber
KW - fruit
KW - nephrolithiasis
KW - urinary calculi
KW - vegetables
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U2 - 10.1016/j.juro.2014.05.086
DO - 10.1016/j.juro.2014.05.086
M3 - Article
C2 - 24859445
AN - SCOPUS:84914159092
SN - 0022-5347
VL - 192
SP - 1694
EP - 1699
JO - Journal of Urology
JF - Journal of Urology
IS - 6
ER -
