Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma

Brian C H Chiu, Soyang Kwon, Andrew M. Evens, Tanya Surawicz, Sonali M. Smith, Dennis D. Weisenburger

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective: Few studies have evaluated the potential association between consumption of fruit and vegetables and non-Hodgkin lymphoma (NHL) by histologic subtype, and the results of these studies have been inconsistent. Methods: A detailed history of dietary practices and food preferences was collected using a food frequency questionnaire from 348 cases and 470 controls in a populationbased, case-control study conducted in Nebraska during 1999-2002. Risk for the highest versus lowest quartile or tertile of intake was estimated by odds ratios (ORs) and 95% confidence interval (CIs). Results: A lower risk of overall NHL was associated with a high intake of green leafy vegetables (OR = 0.6; CI = 0.3-1.0) and cruciferous vegetables (OR = 0.7; CI = 0.4-1.0). Analysis by subtype showed that green leafy vegetable intake was associated with a lower risk of follicular lymphoma (OR = 0.5; CI = 0.3-0.8) and diffuse large B-cell lymphoma (DLBCL) (OR = 0.5; CI = 0.3-0.9), while consumption of cruciferous vegetables was associated with a lower risk of DLBCL (OR = 0.4; CI = 0.2-0.8). No association was found with intake of total vegetables, carotene-rich vegetables, or all fruit. For nutrients, the risk of NHL overall was inversely associated with a higher intake of b-cryptoxanthin (OR = 0.6; CI = 0.4-0.9), magnesium (OR = 0.4; CI = 0.2-0.6), potassium (OR = 0.5; CI = 0.3-1.0), and fiber (OR = 0.6; CI = 0.3-1.0), but positively associated with a higher intake of retinol (OR = 1.7; CI = 1.1-2.8). Intakes of vitamin E, magnesium, and potassium were inversely associated with the risk of DLBCL. Conclusion: A higher intake of green leafy vegetables and cruciferous vegetables is associated with a lower risk of NHL overall, particularly follicular lymphoma and DLBCL.

Original languageEnglish (US)
Pages (from-to)1183-1195
Number of pages13
JournalCancer Causes and Control
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2011

Keywords

  • Antioxidants
  • Diet
  • Non-Hodgkin lymphoma
  • Vegetables

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Chiu, B. C. H., Kwon, S., Evens, A. M., Surawicz, T., Smith, S. M., & Weisenburger, D. D. (2011). Dietary intake of fruit and vegetables and risk of non-Hodgkin lymphoma. Cancer Causes and Control, 22(8), 1183-1195. https://doi.org/10.1007/s10552-011-9797-5