Dietary lipid assimilation after acute ethanol ingestion in the rat

C. L. Mendenhall; P. A. Greenberger; J. C. Greenberger; J. JulianD.

doi:10.1152/ajplegacy.1974.227.2.377

Dietary lipid assimilation after acute ethanol ingestion in the rat

C. L. Mendenhall, P. A. Greenberger, J. C. Greenberger, J. JulianD.

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The acute ingestion of ethanol and a lipid emulsion containing tripalmitin ¹⁴C resulted in the development of a fatty liver within 16 hr. Tagged liver triglycerides increased fourfold, suggesting a substantial increase in the accumulation of dietary lipids. When lipid absorption was evaluated using thoracic duct cannulation, the tagged lipid recovered in the chyle after ethanol treatment was 2 times greater than the controls. When isolated intestinal mucosal cells were prepared from ethanol treated animals, a significant increase in tagged lipid uptake was observed using either palmitate ¹⁴C or monopalmitin ¹⁴C. After 1 min incubation with palmitate ¹⁴C, the tagged fatty acids were recovered unesterified in the membrane fraction of the cells. These studies suggest that some, as yet undefined, ethanol induced alteration in cell membrane is responsible for the observed changes.

Original language	English (US)
Pages (from-to)	377-382
Number of pages	6
Journal	American Journal of Physiology
Volume	227
Issue number	2
DOIs	https://doi.org/10.1152/ajplegacy.1974.227.2.377
State	Published - 1974

ASJC Scopus subject areas

Physiology (medical)

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10.1152/ajplegacy.1974.227.2.377

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title = "Dietary lipid assimilation after acute ethanol ingestion in the rat",

abstract = "The acute ingestion of ethanol and a lipid emulsion containing tripalmitin 14C resulted in the development of a fatty liver within 16 hr. Tagged liver triglycerides increased fourfold, suggesting a substantial increase in the accumulation of dietary lipids. When lipid absorption was evaluated using thoracic duct cannulation, the tagged lipid recovered in the chyle after ethanol treatment was 2 times greater than the controls. When isolated intestinal mucosal cells were prepared from ethanol treated animals, a significant increase in tagged lipid uptake was observed using either palmitate 14C or monopalmitin 14C. After 1 min incubation with palmitate 14C, the tagged fatty acids were recovered unesterified in the membrane fraction of the cells. These studies suggest that some, as yet undefined, ethanol induced alteration in cell membrane is responsible for the observed changes.",

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AU - Greenberger, P. A.

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AB - The acute ingestion of ethanol and a lipid emulsion containing tripalmitin 14C resulted in the development of a fatty liver within 16 hr. Tagged liver triglycerides increased fourfold, suggesting a substantial increase in the accumulation of dietary lipids. When lipid absorption was evaluated using thoracic duct cannulation, the tagged lipid recovered in the chyle after ethanol treatment was 2 times greater than the controls. When isolated intestinal mucosal cells were prepared from ethanol treated animals, a significant increase in tagged lipid uptake was observed using either palmitate 14C or monopalmitin 14C. After 1 min incubation with palmitate 14C, the tagged fatty acids were recovered unesterified in the membrane fraction of the cells. These studies suggest that some, as yet undefined, ethanol induced alteration in cell membrane is responsible for the observed changes.

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Dietary lipid assimilation after acute ethanol ingestion in the rat

Abstract

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