The acute ingestion of ethanol and a lipid emulsion containing tripalmitin 14C resulted in the development of a fatty liver within 16 hr. Tagged liver triglycerides increased fourfold, suggesting a substantial increase in the accumulation of dietary lipids. When lipid absorption was evaluated using thoracic duct cannulation, the tagged lipid recovered in the chyle after ethanol treatment was 2 times greater than the controls. When isolated intestinal mucosal cells were prepared from ethanol treated animals, a significant increase in tagged lipid uptake was observed using either palmitate 14C or monopalmitin 14C. After 1 min incubation with palmitate 14C, the tagged fatty acids were recovered unesterified in the membrane fraction of the cells. These studies suggest that some, as yet undefined, ethanol induced alteration in cell membrane is responsible for the observed changes.
ASJC Scopus subject areas
- Physiology (medical)