DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY

Richard B. Shekelle*, Shuguey Liu, Willam J. Raynor, Mark Lepper, Carol Maliza, Arthur H. Rossof, Oglesby Paul, Anne Macmillan Shryock, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

380 Scopus citations

Abstract

Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.

Original languageEnglish (US)
Pages (from-to)1185-1190
Number of pages6
JournalThe Lancet
Volume318
Issue number8257
DOIs
StatePublished - Nov 28 1981

Funding

Trulson and Ms Dorothea Turner who helped to prepare the food composition table, Dr Harlley McKean and Mr Daniel Garside who helped to organise the data file, Mr Joseph Costello, Mrs Nancy O’Dell, and Mrs Dolores Vogel who assisted in determining the vital status of participants, and Ms Loralei LeGrady who helped to prepare data tables and manuscript. Dr Charles Hennekens and Mr Richard Peto made helpful suggestions on analysis of data. The Western Electric Study has been supported by the American Heart Association; Mrs Tiffany Blake; Chicago Heart Association; Illim Foundation; Illinois Heart Association; National Heart, Lung and Blood Institute; Research and Education Committee of Presbyterian-St Luke’s Hospital; Otho S. Sprague Foundation, and other private donors. This investigation was supported by the Day Fund, the Rush Cancer Center, and the National Cancer Institute (CA 22536).

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY'. Together they form a unique fingerprint.

Cite this