DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY

Richard B. Shekelle; Shuguey Liu; Willam J. Raynor; Mark Lepper; Carol Maliza; Arthur H. Rossof; Oglesby Paul; Anne Macmillan Shryock; Jeremiah Stamler

doi:10.1016/S0140-6736(81)91435-5

DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY

Richard B. Shekelle^*, Shuguey Liu, Willam J. Raynor, Mark Lepper, Carol Maliza, Arthur H. Rossof, Oglesby Paul, Anne Macmillan Shryock, Jeremiah Stamler

^*Corresponding author for this work

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Abstract

Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.

Original language	English (US)
Pages (from-to)	1185-1190
Number of pages	6
Journal	The Lancet
Volume	318
Issue number	8257
DOIs	https://doi.org/10.1016/S0140-6736(81)91435-5
State	Published - Nov 28 1981

Funding

Trulson and Ms Dorothea Turner who helped to prepare the food composition table, Dr Harlley McKean and Mr Daniel Garside who helped to organise the data file, Mr Joseph Costello, Mrs Nancy O’Dell, and Mrs Dolores Vogel who assisted in determining the vital status of participants, and Ms Loralei LeGrady who helped to prepare data tables and manuscript. Dr Charles Hennekens and Mr Richard Peto made helpful suggestions on analysis of data. The Western Electric Study has been supported by the American Heart Association; Mrs Tiffany Blake; Chicago Heart Association; Illim Foundation; Illinois Heart Association; National Heart, Lung and Blood Institute; Research and Education Committee of Presbyterian-St Luke’s Hospital; Otho S. Sprague Foundation, and other private donors. This investigation was supported by the Day Fund, the Rush Cancer Center, and the National Cancer Institute (CA 22536).

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(81)91435-5

Cite this

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title = "DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY",

abstract = "Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.",

author = "Shekelle, {Richard B.} and Shuguey Liu and Raynor, {Willam J.} and Mark Lepper and Carol Maliza and Rossof, {Arthur H.} and Oglesby Paul and Shryock, {Anne Macmillan} and Jeremiah Stamler",

note = "Funding Information: Trulson and Ms Dorothea Turner who helped to prepare the food composition table, Dr Harlley McKean and Mr Daniel Garside who helped to organise the data file, Mr Joseph Costello, Mrs Nancy O{\textquoteright}Dell, and Mrs Dolores Vogel who assisted in determining the vital status of participants, and Ms Loralei LeGrady who helped to prepare data tables and manuscript. Dr Charles Hennekens and Mr Richard Peto made helpful suggestions on analysis of data. The Western Electric Study has been supported by the American Heart Association; Mrs Tiffany Blake; Chicago Heart Association; Illim Foundation; Illinois Heart Association; National Heart, Lung and Blood Institute; Research and Education Committee of Presbyterian-St Luke{\textquoteright}s Hospital; Otho S. Sprague Foundation, and other private donors. This investigation was supported by the Day Fund, the Rush Cancer Center, and the National Cancer Institute (CA 22536).",

year = "1981",

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doi = "10.1016/S0140-6736(81)91435-5",

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AU - Shekelle, Richard B.

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AU - Maliza, Carol

AU - Rossof, Arthur H.

AU - Paul, Oglesby

AU - Shryock, Anne Macmillan

AU - Stamler, Jeremiah

N1 - Funding Information: Trulson and Ms Dorothea Turner who helped to prepare the food composition table, Dr Harlley McKean and Mr Daniel Garside who helped to organise the data file, Mr Joseph Costello, Mrs Nancy O’Dell, and Mrs Dolores Vogel who assisted in determining the vital status of participants, and Ms Loralei LeGrady who helped to prepare data tables and manuscript. Dr Charles Hennekens and Mr Richard Peto made helpful suggestions on analysis of data. The Western Electric Study has been supported by the American Heart Association; Mrs Tiffany Blake; Chicago Heart Association; Illim Foundation; Illinois Heart Association; National Heart, Lung and Blood Institute; Research and Education Committee of Presbyterian-St Luke’s Hospital; Otho S. Sprague Foundation, and other private donors. This investigation was supported by the Day Fund, the Rush Cancer Center, and the National Cancer Institute (CA 22536).

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N2 - Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.

AB - Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.

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IS - 8257

ER -

DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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