TY - JOUR
T1 - DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY
AU - Shekelle, Richard B.
AU - Liu, Shuguey
AU - Raynor, Willam J.
AU - Lepper, Mark
AU - Maliza, Carol
AU - Rossof, Arthur H.
AU - Paul, Oglesby
AU - Shryock, Anne Macmillan
AU - Stamler, Jeremiah
N1 - Funding Information:
Trulson and Ms Dorothea Turner who helped to prepare the food composition table, Dr Harlley McKean and Mr Daniel Garside who helped to organise the data file, Mr Joseph Costello, Mrs Nancy O’Dell, and Mrs Dolores Vogel who assisted in determining the vital status of participants, and Ms Loralei LeGrady who helped to prepare data tables and manuscript. Dr Charles Hennekens and Mr Richard Peto made helpful suggestions on analysis of data. The Western Electric Study has been supported by the American Heart Association; Mrs Tiffany Blake; Chicago Heart Association; Illim Foundation; Illinois Heart Association; National Heart, Lung and Blood Institute; Research and Education Committee of Presbyterian-St Luke’s Hospital; Otho S. Sprague Foundation, and other private donors. This investigation was supported by the Day Fund, the Rush Cancer Center, and the National Cancer Institute (CA 22536).
PY - 1981/11/28
Y1 - 1981/11/28
N2 - Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.
AB - Intake of dietary provitamin A (carotene) was inversely related to the 19-year incidence of lung cancer in a prospective epidemiological study of 1954 middle-aged men. The relative risks of lung cancer in the first (lowest) to fourth quartiles of the distribution of carotene intake were respectively, 7·0, 5· 5, 3.0, and 1.0 for all men in the study, and 8· 1, 5.6, 3.9, and 1.0 for men who had smoked cigarettes for 30 or more years. Intake of preformed vitamin A (retinol) and intake of other nutrients were not significantly related to the risk of lung cancer. Neither carotene nor retinol intake was significantly related to the risk of other carcinomas grouped together, although for men in whom epidermoid carcinomas of the head and neck subsequently developed, carotene intake tended to be below average. These results support the hypothesis that dietary beta-carotene decreases the risk of lung cancer. However, cigarette smoking also increases the risk of serious diseases other than lung cancer, and there is no evidence that dietary carotenoids affect these other risks in any way.
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U2 - 10.1016/S0140-6736(81)91435-5
DO - 10.1016/S0140-6736(81)91435-5
M3 - Article
C2 - 6118627
AN - SCOPUS:0019808394
SN - 0140-6736
VL - 318
SP - 1185
EP - 1190
JO - The Lancet
JF - The Lancet
IS - 8257
ER -
