Dietary vitamin c and β-carotene and risk of death in middle-aged men: The western electric study

Dilip K. Pandey*, Richard Shekelle, Beatrice J. Selwyn, Christine Tangney, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


In the Western Electric Company Study, carried out in Chicago, Illinois, data on diet and other factors were obtained in 1958 and 1959 for a cohort of 1,556 employed, middle-aged men. Nutrients included vitamin C and β-carotene. An index that summarized combined intake of both nutrients was constructed. Mean intakes of vitamin C in the lowest and highest tertiles of the index were 66 and 138 mg/day; corresponding values for β-carotene were 2.3 and 5.3 mg/day. A total of 522 of 1,556 men died during 32,935 person-years of follow-up, 231 from coronary heart disease and 155 from cancer. After adjustment for potentially confounding factors, relative risks (95% confidence intervals) associated with an increment of 19 points in the index (difference between means of the lowest and highest tertiles) were 0.60 (0.39-0.93) for cancer mortality, 0.70 (0.49-0.98) for coronary disease mortality, and 0.69 (0.55-0.87) for all-cause mortality. These results support the hypothesis that consumption of foods rich in vitamin C and β-carotene reduces risk of death in middleaged men.

Original languageEnglish (US)
Pages (from-to)1269-1278
Number of pages10
JournalAmerican journal of epidemiology
Issue number12
StatePublished - Dec 15 1995


  • Antioxidants
  • Cohort studies
  • Coronary disease
  • Diet
  • Mortality

ASJC Scopus subject areas

  • Epidemiology


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