Differences in clinical outcomes in patients with vancomycin-resistant enterococci according to linezolid susceptibility

Marc H. Scheetz, Stephanie A. Knechtel, Michael J. Postelnick, Michael Malczynski, Chao Qi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Study Objective. To evaluate the differences in clinical outcomes in patients with linezolid-intermediate or -resistant vancomycin-resistant enterococci (LIRVRE) isolates, as defined by the presence of the G2576T mutation, compared with patients who had linezolid-susceptible VRE (LSVRE) isolates in order to further discern the clinical relevance of linezolid resistance associated with this mutation. Design. Retrospective cohort study. Setting. Large tertiary care academic medical center. Patients. Eighteen adults (mean age 55.4 yrs) with LIRVRE (case patients) who were frequency matched to 54 adults (mean age 58.1 yrs) with LSVRE (control patients) in a 1:3 ratio based on site of culture and VRE species. Measurements and Main Results. Linezolid resistance was determined by phenotype and genotype (G2576T mutation by polymerase chain reaction). Patients with LIRVRE received more linezolid before isolation of the organism than did those with LSVRE (mean 8.6 vs 0.2 days, p<0.001). No difference in mortality was found; however, compared with controls, patients with LIRVRE were more likely to be transferred to the intensive care unit (56% vs 28%, p=0.032), had more surgical procedures for VRE (39% vs 15%, p=0.029), and had more echocardiograms performed (44% vs 19%, p=0.028) as a result of their VRE. Multivariate analysis revealed that surviving case patients had an increased duration of culture positivity of approximately 1.5 days (p=0.049) and a near statistically significant increase of postculture length of stay of approximately 2 days (p=0.053). Conclusion. The clinical relevance of the G2576T mutation among enterococci remains unclear; however, the increased morbidity and resource utilization among patients with LIRVRE is a finding of concern. Careful monitoring of genotypically confirmed LIRVRE emergence and ongoing epidemiologic studies will be critical to better characterize the clinical relevance of linezolid resistance.

Original languageEnglish (US)
Pages (from-to)1221-1228
Number of pages8
JournalPharmacotherapy
Volume30
Issue number12
DOIs
StatePublished - Dec 1 2010

Keywords

  • Antibiotic resistance
  • Enterococcus
  • G2576T
  • Linezolid resistance
  • VRE
  • Vancomycin-resistant enterococci

ASJC Scopus subject areas

  • Pharmacology (medical)

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