Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size

Zoran B. Popović, Jing Ping Sun, Hirotsugu Yamada, Jeannie Drinko, Karin Mauer, Neil L. Greenberg, Yuanna Cheng, Christine S. Moravec, Marc S. Penn, Todor N. Mazgalev, James D. Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

While the heart size maintains a constant proportion to body size, heart function parameters, such as heart rate and cardiac output, show a more complex scaling pattern. How these phenomena affect the long-axis left ventricular (LV) function is unknown. We studied 10 mice, 15 rats, 6 rabbits, 8 mongrel dogs and 38 human volunteers. Doppler tissue echocardiography data were postprocessed to reconstruct mitral annulus (MA) peak systolic velocity and displacement. The relationship between MA peak velocity, MA displacement and LV ejection time, and LV end-diastolic volume (and mass) were fit to an allometric (power-law) equation Y = kMβ. LV mass varied from 0.062 to 255 g, while end-diastolic volume varied from 0.014 to 205 ml. β values of the relation between LV ejection time and LV end-diastolic volume and mass were 0.247 ± 0.017 and 0.267 ± 0.018, respectively. β values of the relationship between MA displacement and LV end-diastolic volume and mass were 0.358 ± 0.047 and 0.390 ± 0.051 (P < 0.023 versus β of LV ejection time). β values of the relationship between MA peak systolic velocity and LV end-diastolic volume and mass were 0.096 ± 0.012 and 0.100 ± 0.013, respectively (P < 0.0001 versus 0). Finally, β values of the relationship between the long-to-short axis displacement ratio and LV end-diastolic volume and mass were 0.077 ± 0.017 and 0.086 ± 0.019 (P < 0.0001 versus 0). We conclude that MA velocity, displacement, and long-to-short axis displacement ratio scale allometrically to heart size. This reduces the relative long-axis contribution to heart function in small mammals.

Original languageEnglish (US)
Pages (from-to)255-265
Number of pages11
JournalJournal of Physiology
Volume568
Issue number1
DOIs
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Physiology

Fingerprint Dive into the research topics of 'Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size'. Together they form a unique fingerprint.

  • Cite this

    Popović, Z. B., Sun, J. P., Yamada, H., Drinko, J., Mauer, K., Greenberg, N. L., Cheng, Y., Moravec, C. S., Penn, M. S., Mazgalev, T. N., & Thomas, J. D. (2005). Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size. Journal of Physiology, 568(1), 255-265. https://doi.org/10.1113/jphysiol.2005.090779