Differences in the time course of haloperidol-induced up-regulation of rat striatal and mesolimbic dopamine receptors

Elisabeth S. Prosser; John G. Csernansky; Leo E. Hollister

doi:10.1016/0024-3205(88)90143-9

Differences in the time course of haloperidol-induced up-regulation of rat striatal and mesolimbic dopamine receptors

Elisabeth S. Prosser^*, John G. Csernansky, Leo E. Hollister

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Regional differences in the onset and persistence of increased dopamine D2 receptor density in rat brain were studied following daily injections of haloperidol for 3, 7, 14, or 28 days. Striatal [³H] - spiroperidol Bmax values were significantly increased following 3 - 28 days of haloperidol treatment, as compared to saline controls. Olfactory tubercle Bmax values were significantly increased only after 14 or 28 days of haloperidol treatment. Nucleus accumbens Bmax values were significantly increased only in the 14-day drug treatment group, suggesting that dopamine D2 receptor up-regulation in nucleus accumbens may reverse during ongoing neuroleptic treatment. These findings suggest that important differences in adaptive responses to chronic dopamine blockade may exist between dopaminergic synapses located in various rat brain regions.

Original language	English (US)
Pages (from-to)	715-720
Number of pages	6
Journal	Life Sciences
Volume	43
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(88)90143-9
State	Published - 1988

Funding

This work was supported by a Veterans Administration Career Development Award to EP, the Schizophrenia Biologic Research Center at the Palo Alto Veterans Administration Medical Center, and a grant from the National Institute of Mental Health (MH-30854) to the VA-Stanford Mental Health Research Center.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(88)90143-9

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title = "Differences in the time course of haloperidol-induced up-regulation of rat striatal and mesolimbic dopamine receptors",

abstract = "Regional differences in the onset and persistence of increased dopamine D2 receptor density in rat brain were studied following daily injections of haloperidol for 3, 7, 14, or 28 days. Striatal [3H] - spiroperidol Bmax values were significantly increased following 3 - 28 days of haloperidol treatment, as compared to saline controls. Olfactory tubercle Bmax values were significantly increased only after 14 or 28 days of haloperidol treatment. Nucleus accumbens Bmax values were significantly increased only in the 14-day drug treatment group, suggesting that dopamine D2 receptor up-regulation in nucleus accumbens may reverse during ongoing neuroleptic treatment. These findings suggest that important differences in adaptive responses to chronic dopamine blockade may exist between dopaminergic synapses located in various rat brain regions.",

author = "Prosser, {Elisabeth S.} and Csernansky, {John G.} and Hollister, {Leo E.}",

note = "Funding Information: This work was supported by a Veterans Administration Career Development Award to EP, the Schizophrenia Biologic Research Center at the Palo Alto Veterans Administration Medical Center, and a grant from the National Institute of Mental Health (MH-30854) to the VA-Stanford Mental Health Research Center.",

year = "1988",

doi = "10.1016/0024-3205(88)90143-9",

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volume = "43",

pages = "715--720",

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AU - Prosser, Elisabeth S.

AU - Csernansky, John G.

AU - Hollister, Leo E.

N1 - Funding Information: This work was supported by a Veterans Administration Career Development Award to EP, the Schizophrenia Biologic Research Center at the Palo Alto Veterans Administration Medical Center, and a grant from the National Institute of Mental Health (MH-30854) to the VA-Stanford Mental Health Research Center.

PY - 1988

Y1 - 1988

N2 - Regional differences in the onset and persistence of increased dopamine D2 receptor density in rat brain were studied following daily injections of haloperidol for 3, 7, 14, or 28 days. Striatal [3H] - spiroperidol Bmax values were significantly increased following 3 - 28 days of haloperidol treatment, as compared to saline controls. Olfactory tubercle Bmax values were significantly increased only after 14 or 28 days of haloperidol treatment. Nucleus accumbens Bmax values were significantly increased only in the 14-day drug treatment group, suggesting that dopamine D2 receptor up-regulation in nucleus accumbens may reverse during ongoing neuroleptic treatment. These findings suggest that important differences in adaptive responses to chronic dopamine blockade may exist between dopaminergic synapses located in various rat brain regions.

AB - Regional differences in the onset and persistence of increased dopamine D2 receptor density in rat brain were studied following daily injections of haloperidol for 3, 7, 14, or 28 days. Striatal [3H] - spiroperidol Bmax values were significantly increased following 3 - 28 days of haloperidol treatment, as compared to saline controls. Olfactory tubercle Bmax values were significantly increased only after 14 or 28 days of haloperidol treatment. Nucleus accumbens Bmax values were significantly increased only in the 14-day drug treatment group, suggesting that dopamine D2 receptor up-regulation in nucleus accumbens may reverse during ongoing neuroleptic treatment. These findings suggest that important differences in adaptive responses to chronic dopamine blockade may exist between dopaminergic synapses located in various rat brain regions.

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Differences in the time course of haloperidol-induced up-regulation of rat striatal and mesolimbic dopamine receptors

Abstract

Funding

ASJC Scopus subject areas

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