Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging

Maria Angela Sorting, Grazia Aleppo, Umberto Scapagnini, Pier Luigi Canonico

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

GnRH release from hypothalamic explants from young and aged male Wistar- Kyoto rats was evaluated following stimulation with glutamate receptor agonists. Glutamate stimulated GnRH release to a similar extent in hypothalami from young and old animals, whereas N-methyl-D-Aspartate (NMDA) and kainate appeared more efficacious in young and old rats, respectively. Old rats were unable to respond to a maximal stimulating concentration of glutamate when they had been previously exposed to a challenge with the same agent. These results demonstrate that responsiveness to glutamate receptor agonists changes during aging, suggesting the involvement of distinct glutamate receptors in the control of GnRH release during different phases of lifespan.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalBrain Research Bulletin
Volume41
Issue number6
DOIs
StatePublished - Dec 1 1996

Keywords

  • Aging
  • Excitatory amino acids
  • GnRH
  • Hypothalamus

ASJC Scopus subject areas

  • Neuroscience(all)

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