Differential amygdala responses to winning and losing: A functional magnetic resonance imaging study in humans

Tiziana Zalla, Etienne Koechlin, Pietro Pietrini, Gianpaolo Basso, Patrick Aquino, Angela Sirigu, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

The amygdala has been shown to respond to many distinct types of affective stimuli, including reward and punishment feedback in animals. In humans, winning and losing situations can be considered as reward and punishment experiences, respectively. In this study, we used functional magnetic resonance imaging (fMRI) to measure regional brain activity when human subjects were given feedback on their performance during a simple response time task in a fictitious competitive tournament. Lexical stimuli were used to convey positive 'win' or negative 'lose' feedback. The frequency of positive and negative trials was parametrically varied by the experimenters independently from the subjects' actual performance and unbeknownst to them. The results showed that the parametric increase of winning was associated with left amygdala activation whereas the parametric increase of losing was associated with right amygdala activation. These findings provide functional evidence that the human amygdala differentially responds to changes in magnitude of positive or negative reinforcement conveyed by lexical stimuli.

Original languageEnglish (US)
Pages (from-to)1764-1770
Number of pages7
JournalEuropean Journal of Neuroscience
Volume12
Issue number5
DOIs
Publication statusPublished - May 24 2000

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Keywords

  • Brain
  • Competition
  • Emotion
  • Motivation
  • Punishment
  • Reward

ASJC Scopus subject areas

  • Neuroscience(all)

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