Differential diagnosis of pediatric multiple sclerosis

Maria Milagros Galardi, Cristina Gaudioso, Saumel Ahmadi, Emily Evans, Laura Gilbert, Soe Mar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The differential diagnosis of pediatric multiple sclerosis (MS) can be broad and pose diagnostic challenges, particularly at initial presentation. Among demyelinating entities, neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated disorders, and acute disseminated encephalomyelitis (ADEM) are now well-known as unique disease processes and yet continue to overlap with MS in regards to clinical presentation and imaging. In non-inflammatory entities, such as metabolic disorders and leukodystrophies, an erroneous diagnosis of MS can be made even while applying appropriate diagnostic criteria. Knowing the epidemiology, typical clinical presentation, diagnostic criteria, and ancillary test results in each disease, can aid in making the correct diagnosis by contrasting these features with those of pediatric MS. Determining the correct diagnosis early, allows for efficient and effective treatment as well as appropriate prognostication.

Original languageEnglish (US)
Article number75
Issue number6
StatePublished - Jun 2019


  • ADEM
  • Demyelination
  • Leukodystrophies
  • MOG-ab
  • Metabolic disorders
  • Pediatric multiple sclerosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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