Differential distribution of a neurofilament protein epitope in acetylcholinesterase-rich neurons of human cerebral neocortex

Marsel Mesulam*, Changiz Geula

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The majority of acetylcholinesterase-rich pyramidal neurons in neocortical layers III and V of the human brain displayed intense immunostaining with SMI-32, a monoclonal antibody which recognizes a non-phosphorylated epitope of neurofilament proteins. In contrast, very few of the heteromorphic acetylcholinesterase-rich perikarya embedded in the white matter of the cerebral hemispheres are associated with this type of immunostaining. These two groups of acetylcholinesterase-rich cortical neurons can thus be differentiated not only on the basis of morphology and location but also on the basis of cytochemical signature. The concurrent visualization of SMI-32 immunoreactivity and acetylcholinesterase enzyme activity also showed that SMI-32 immunoreactive neurons can be subdivided into several subgroups on the basis of their perikaryal acetylcholinesterase activity.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalBrain research
Volume544
Issue number1
DOIs
StatePublished - Mar 22 1991

Keywords

  • Acetylcholinesterase
  • Alzheimer's disease
  • Cerebral cortex
  • Cytoskeleton
  • Development
  • Human brain
  • Neurofilament protein
  • SMI-32

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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