Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites

Béatrice Marcelin; Joaquin N. Lugo; Amy L. Brewster; Zhiqiang Liu; Alan S. Lewis; Shawn McClelland; Dane M. Chetkovich; Tallie Z. Baram; Anne E. Anderson; Albert Becker; Monique Esclapez; Christophe Bernard

doi:10.1074/jbc.C112.367110

Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites

Béatrice Marcelin, Joaquin N. Lugo, Amy L. Brewster, Zhiqiang Liu, Alan S. Lewis, Shawn McClelland, Dane M. Chetkovich, Tallie Z. Baram, Anne E. Anderson, Albert Becker, Monique Esclapez, Christophe Bernard^*

^*Corresponding author for this work

Neurology

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38 Scopus citations

Abstract

The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place.Wereport enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) upregulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.

Original language	English (US)
Pages (from-to)	17656-17661
Number of pages	6
Journal	Journal of Biological Chemistry
Volume	287
Issue number	21
DOIs	https://doi.org/10.1074/jbc.C112.367110
State	Published - May 18 2012

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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10.1074/jbc.C112.367110

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Marcelin, B., Lugo, J. N., Brewster, A. L., Liu, Z., Lewis, A. S., McClelland, S., Chetkovich, D. M., Baram, T. Z., Anderson, A. E., Becker, A., Esclapez, M., & Bernard, C. (2012). Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. Journal of Biological Chemistry, 287(21), 17656-17661. https://doi.org/10.1074/jbc.C112.367110

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title = "Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites",

abstract = "The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place.Wereport enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) upregulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.",

author = "B{\'e}atrice Marcelin and Lugo, {Joaquin N.} and Brewster, {Amy L.} and Zhiqiang Liu and Lewis, {Alan S.} and Shawn McClelland and Chetkovich, {Dane M.} and Baram, {Tallie Z.} and Anderson, {Anne E.} and Albert Becker and Monique Esclapez and Christophe Bernard",

year = "2012",

month = may,

day = "18",

doi = "10.1074/jbc.C112.367110",

language = "English (US)",

volume = "287",

pages = "17656--17661",

journal = "Journal of Biological Chemistry",

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Marcelin, B, Lugo, JN, Brewster, AL, Liu, Z, Lewis, AS, McClelland, S, Chetkovich, DM, Baram, TZ, Anderson, AE, Becker, A, Esclapez, M & Bernard, C 2012, 'Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites', Journal of Biological Chemistry, vol. 287, no. 21, pp. 17656-17661. https://doi.org/10.1074/jbc.C112.367110

Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. / Marcelin, Béatrice; Lugo, Joaquin N.; Brewster, Amy L. et al.
In: Journal of Biological Chemistry, Vol. 287, No. 21, 18.05.2012, p. 17656-17661.

Research output: Contribution to journal › Article › peer-review

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T1 - Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites

AU - Marcelin, Béatrice

AU - Lugo, Joaquin N.

AU - Brewster, Amy L.

AU - Liu, Zhiqiang

AU - Lewis, Alan S.

AU - McClelland, Shawn

AU - Chetkovich, Dane M.

AU - Baram, Tallie Z.

AU - Anderson, Anne E.

AU - Becker, Albert

AU - Esclapez, Monique

AU - Bernard, Christophe

PY - 2012/5/18

Y1 - 2012/5/18

N2 - The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place.Wereport enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) upregulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.

AB - The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place.Wereport enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) upregulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.

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Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites

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