TY - JOUR
T1 - Differential effect of morphine on trigeminal nucleus versus reticular aversive stimulation
T2 - Independence of negative effects from stimulation parameters
AU - Rosenfeld, J. Peter
AU - Vickery, Jon L.
N1 - Funding Information:
Supported by NIH Grants GM23696-01. 5-50-RR07028 and F’R7028-05, and NSF Grant 75-17770 (J.P.R.). A preliminary report of portions of these data was presented at the 5th Annual Meeting of the Society for Neuroscience, NYC, November, 1975.
PY - 1976/12
Y1 - 1976/12
N2 - Electrodes were implanted in mesencephalic, pontine, and bulbar reticularformation, and in spinal trigeminal nucleus and tract of rats. Central and peripheral aversive response thresholds were studied under normal conditions and with morphine. Peripherally elicited aversive reactions were assessed with tail-flick, hot-plate, and footshock responses. Centrally elicited aversive reaction thresholds were in all cases based on unconditioned behavioral distress signs (non-stereotyped, escape-like movements, vocalization, freezing, excretion, etc.) and confirmed in some cases with avoidance learning. Morphine (10 mg/kg) elevated the unconditioned aversive reaction threshold for brain stimulation in the trigeminal complex and for peripheral aversive stimulation, but failed to affect the thresholds for reticular brain stimulation. The failure to affect reticular thresholds was independent of stimulation frequency. Thresholds for 5 and 200 Hz sinusoidal stimulation were both unaffected as were previously reported thresholds with 333 Hz pulsatile stimulation. Trigeminal nucleus and tract stimulation were affected in similar degrees. The data were discussed as supporting descending inhibitory models of opiate analgesia.
AB - Electrodes were implanted in mesencephalic, pontine, and bulbar reticularformation, and in spinal trigeminal nucleus and tract of rats. Central and peripheral aversive response thresholds were studied under normal conditions and with morphine. Peripherally elicited aversive reactions were assessed with tail-flick, hot-plate, and footshock responses. Centrally elicited aversive reaction thresholds were in all cases based on unconditioned behavioral distress signs (non-stereotyped, escape-like movements, vocalization, freezing, excretion, etc.) and confirmed in some cases with avoidance learning. Morphine (10 mg/kg) elevated the unconditioned aversive reaction threshold for brain stimulation in the trigeminal complex and for peripheral aversive stimulation, but failed to affect the thresholds for reticular brain stimulation. The failure to affect reticular thresholds was independent of stimulation frequency. Thresholds for 5 and 200 Hz sinusoidal stimulation were both unaffected as were previously reported thresholds with 333 Hz pulsatile stimulation. Trigeminal nucleus and tract stimulation were affected in similar degrees. The data were discussed as supporting descending inhibitory models of opiate analgesia.
UR - http://www.scopus.com/inward/record.url?scp=0017167761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017167761&partnerID=8YFLogxK
U2 - 10.1016/0304-3959(76)90081-6
DO - 10.1016/0304-3959(76)90081-6
M3 - Article
C2 - 1028023
AN - SCOPUS:0017167761
VL - 2
SP - 405
EP - 416
JO - Pain
JF - Pain
SN - 0304-3959
IS - 4
ER -