Differential effects of inhibitors of monoamine oxidase types A and B on the adrenergic system of the rabbit iris

E. A. Zeller, Paul A Knepper, D. Shoch

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Topical installation of inhibitors of monoamine oxidase types A or B into the rabbit eye, followed by the administration of a releaser of monoamines (Ro 4 1284), induces strong and sustained dilation of the iris. The mydriatic pattern differs markedly with A and B inhibitors and with the duration of the inhibitor treatment. The type B inhibitor, deprenyl, prevents the degradation of exogenous 2 phenylethylamine and possibly of the endogenous amine X capable of releasing monoamines from a compartment less accessible to Ro 4 1284.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalInvestigative Ophthalmology
Volume14
Issue number2
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Medicine(all)

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