Differential effects of proglumide on mesolimbic and nigrostriatal dopamine function

J. G. Csernansky*, S. Glick, J. Mellentin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Cholecystokinin octapeptide (CCK-8) is prevalent as a co-transmitter in the mesolimbic dopamine pathway. The effect of proglumide, a CCK-8 antagonist, on two acute and one chronic behavioral models of dopamine function was tested. First, haloperidol was used to inhibit stereotypies induced by apomorphine in rats. Pre-administration of proglumide significantly shifted the haloperidol dose response curve to the left. Second, rats were injected in the left caudate nucleus with kainic acid. Three weeks later, haloperidol was used to inhibit apomorphine-induced circling. Pre-administration of proglumide had no effect on this haloperidol dose response curve. Third, either proglumide, haloperidol, or combined treatment was administered to rats for 2 weeks. In proglumide-treated animals, a significant increase in 3H-spiperone binding sites in the nucleus accumbens was observed.

Original languageEnglish (US)
Pages (from-to)440-444
Number of pages5
JournalPsychopharmacology
Volume91
Issue number4
DOIs
StatePublished - Apr 1987

Keywords

  • CCK-8
  • Dopamine
  • Mesolimbic
  • Nigrostriatal
  • Proglumide

ASJC Scopus subject areas

  • Pharmacology

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